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100 1 _ |a Chen, La
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245 _ _ |a Characterization of the mechanical properties of HL-1 cardiomyocytes with high throughput magnetic tweezers
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520 _ _ |a We characterized the mechanical properties of cardiomyocyte-like HL-1 cells using our recently developed multi-pole magnetic tweezers. With the optimized design, both high force and high throughput are achieved at the same time. Force up to 100 pN can be applied on a 1 μm diameter superparamagnetic bead in a workspace with 60 μm radius, which is encircled symmetrically by 3 sharp magnetic tips. By adjusting the coil currents, both the strength and direction of force can be controlled. The result shows that both viscosity and shear elastic modulus of HL-1 cells exhibit an approximately log-normal distribution. The cells became stiffer as they matured, consistent with a transition from proliferating cells to contractile muscle tissue. Moreover, the mechanical properties of HL-1 cells show high heterogeneity, which agrees well with their physiological structure.
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700 1 _ |a Offenhäusser, Andreas
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700 1 _ |a Krause, Hans-Joachim
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773 _ _ |a 10.1063/1.4928322
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