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000021087 0247_ $$2DOI$$a10.1002/pssa.201100710
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000021087 084__ $$2WoS$$aMaterials Science, Multidisciplinary
000021087 084__ $$2WoS$$aPhysics, Applied
000021087 084__ $$2WoS$$aPhysics, Condensed Matter
000021087 1001_ $$0P:(DE-Juel1)VDB103994$$aAbouzar, M.H.$$b0$$uFZJ
000021087 245__ $$aLabel-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling
000021087 260__ $$aWeinheim$$bWiley-VCH$$c2012
000021087 300__ $$a925 - 934
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000021087 440_0 $$04913$$aPhysica Status Solidi A$$v209$$x0031-8965$$y5
000021087 500__ $$aThe authors thank X. T. Vu and J. Gun for valuable discussions. A. G. Cherstvy gratefully acknowledges the financial support by the Deutsche Forschungsgemeinschaft (DFG Grant CH 707/5-1).
000021087 520__ $$aLabel-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface. (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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000021087 65320 $$2Author$$aDNA
000021087 65320 $$2Author$$afield-effect
000021087 65320 $$2Author$$agold nanoparticle
000021087 65320 $$2Author$$alabel-free detection
000021087 65320 $$2Author$$ananoplate capacitor
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000021087 7001_ $$0P:(DE-Juel1)VDB1267$$aPoghossian, A.$$b1$$uFZJ
000021087 7001_ $$0P:(DE-Juel1)VDB97674$$aCherstvy, A.G.$$b2$$uFZJ
000021087 7001_ $$0P:(DE-Juel1)VDB106554$$aPedraza, A.MN.$$b3$$uFZJ
000021087 7001_ $$0P:(DE-Juel1)VDB5728$$aIngebrandt, S.$$b4$$uFZJ
000021087 7001_ $$0P:(DE-Juel1)128727$$aSchöning, M.J.$$b5$$uFZJ
000021087 773__ $$0PERI:(DE-600)1481091-8$$a10.1002/pssa.201100710$$gVol. 209, p. 925 - 934$$n5$$p925 - 934$$q209<925 - 934$$tPhysica status solidi / A$$v209$$x0031-8965$$y2012
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