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@ARTICLE{Abouzar:21087,
author = {Abouzar, M.H. and Poghossian, A. and Cherstvy, A.G. and
Pedraza, A.MN. and Ingebrandt, S. and Schöning, M.J.},
title = {{L}abel-free electrical detection of {DNA} by means of
field-effect nanoplate capacitors: {E}xperiments and
modeling},
journal = {Physica status solidi / A},
volume = {209},
number = {5},
issn = {0031-8965},
address = {Weinheim},
publisher = {Wiley-VCH},
reportid = {PreJuSER-21087},
pages = {925 - 934},
year = {2012},
note = {The authors thank X. T. Vu and J. Gun for valuable
discussions. A. G. Cherstvy gratefully acknowledges the
financial support by the Deutsche Forschungsgemeinschaft
(DFG Grant CH 707/5-1).},
abstract = {Label-free electrical detection of consecutive
deoxyribonucleic acid (DNA) hybridization/denaturation by
means of an array of individually addressable
field-effect-based nanoplate silicon-on-insulator (SOI)
capacitors modified with gold nanoparticles (Au-NP) is
investigated. The proposed device detects charge changes on
Au-NP/DNA hybrids induced by the hybridization or
denaturation event. DNA hybridization was performed in a
high ionic-strength solution to provide a high hybridization
efficiency. On the other hand, to reduce the screening of
the DNA charge by counter ions and to achieve a high
sensitivity, the sensor signal induced by the hybridization
and denaturation events was measured in a low ionic-strength
solution. High sensor signals of about 120, 90, and 80 mV
were registered after the DNA hybridization, denaturation,
and re-hybridization events, respectively. Fluorescence
microscopy has been applied as reference method to verify
the DNA immobilization, hybridization, and denaturation
processes. An electrostatic charge-plane model for potential
changes at the gate surface of a nanoplate field-effect
sensor induced by the DNA hybridization has been developed
taking into account both the Debye length and the distance
of the DNA charge from the gate surface. (c) 2012 WILEY-VCH
Verlag GmbH $\&$ Co. KGaA, Weinheim},
keywords = {J (WoSType)},
cin = {ICS-2 / PGI-8 / JARA-FIT},
ddc = {530},
cid = {I:(DE-Juel1)ICS-2-20110106 / I:(DE-Juel1)PGI-8-20110106 /
$I:(DE-82)080009_20140620$},
pnm = {BioSoft: Makromolekulare Systeme und biologische
Informationsverarbeitung / 423 - Sensorics and bioinspired
systems (POF2-423)},
pid = {G:(DE-Juel1)FUEK505 / G:(DE-HGF)POF2-423},
shelfmark = {Materials Science, Multidisciplinary / Physics, Applied /
Physics, Condensed Matter},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000303386900021},
doi = {10.1002/pssa.201100710},
url = {https://juser.fz-juelich.de/record/21087},
}