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@ARTICLE{Abouzar:21087,
      author       = {Abouzar, M.H. and Poghossian, A. and Cherstvy, A.G. and
                      Pedraza, A.MN. and Ingebrandt, S. and Schöning, M.J.},
      title        = {{L}abel-free electrical detection of {DNA} by means of
                      field-effect nanoplate capacitors: {E}xperiments and
                      modeling},
      journal      = {Physica status solidi / A},
      volume       = {209},
      number       = {5},
      issn         = {0031-8965},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {PreJuSER-21087},
      pages        = {925 - 934},
      year         = {2012},
      note         = {The authors thank X. T. Vu and J. Gun for valuable
                      discussions. A. G. Cherstvy gratefully acknowledges the
                      financial support by the Deutsche Forschungsgemeinschaft
                      (DFG Grant CH 707/5-1).},
      abstract     = {Label-free electrical detection of consecutive
                      deoxyribonucleic acid (DNA) hybridization/denaturation by
                      means of an array of individually addressable
                      field-effect-based nanoplate silicon-on-insulator (SOI)
                      capacitors modified with gold nanoparticles (Au-NP) is
                      investigated. The proposed device detects charge changes on
                      Au-NP/DNA hybrids induced by the hybridization or
                      denaturation event. DNA hybridization was performed in a
                      high ionic-strength solution to provide a high hybridization
                      efficiency. On the other hand, to reduce the screening of
                      the DNA charge by counter ions and to achieve a high
                      sensitivity, the sensor signal induced by the hybridization
                      and denaturation events was measured in a low ionic-strength
                      solution. High sensor signals of about 120, 90, and 80 mV
                      were registered after the DNA hybridization, denaturation,
                      and re-hybridization events, respectively. Fluorescence
                      microscopy has been applied as reference method to verify
                      the DNA immobilization, hybridization, and denaturation
                      processes. An electrostatic charge-plane model for potential
                      changes at the gate surface of a nanoplate field-effect
                      sensor induced by the DNA hybridization has been developed
                      taking into account both the Debye length and the distance
                      of the DNA charge from the gate surface. (c) 2012 WILEY-VCH
                      Verlag GmbH $\&$ Co. KGaA, Weinheim},
      keywords     = {J (WoSType)},
      cin          = {ICS-2 / PGI-8 / JARA-FIT},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-2-20110106 / I:(DE-Juel1)PGI-8-20110106 /
                      $I:(DE-82)080009_20140620$},
      pnm          = {BioSoft: Makromolekulare Systeme und biologische
                      Informationsverarbeitung / 423 - Sensorics and bioinspired
                      systems (POF2-423)},
      pid          = {G:(DE-Juel1)FUEK505 / G:(DE-HGF)POF2-423},
      shelfmark    = {Materials Science, Multidisciplinary / Physics, Applied /
                      Physics, Condensed Matter},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000303386900021},
      doi          = {10.1002/pssa.201100710},
      url          = {https://juser.fz-juelich.de/record/21087},
}