Home > Publications database > Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling > print

001     21087
005     20240610121009.0
024 7 _ |2 DOI
|a 10.1002/pssa.201100710
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041 _ _ |a eng
082 _ _ |a 530
084 _ _ |2 WoS
|a Materials Science, Multidisciplinary
084 _ _ |2 WoS
|a Physics, Applied
084 _ _ |2 WoS
|a Physics, Condensed Matter
100 1 _ |0 P:(DE-Juel1)VDB103994
|a Abouzar, M.H.
|b 0
|u FZJ
245 _ _ |a Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling
260 _ _ |a Weinheim
|b Wiley-VCH
|c 2012
300 _ _ |a 925 - 934
336 7 _ |a Journal Article
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440 _ 0 |0 4913
|a Physica Status Solidi A
|v 209
|x 0031-8965
|y 5
500 _ _ |a The authors thank X. T. Vu and J. Gun for valuable discussions. A. G. Cherstvy gratefully acknowledges the financial support by the Deutsche Forschungsgemeinschaft (DFG Grant CH 707/5-1).
520 _ _ |a Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface. (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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653 2 0 |2 Author
|a DNA
653 2 0 |2 Author
|a field-effect
653 2 0 |2 Author
|a gold nanoparticle
653 2 0 |2 Author
|a label-free detection
653 2 0 |2 Author
|a nanoplate capacitor
700 1 _ |0 P:(DE-Juel1)VDB1267
|a Poghossian, A.
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700 1 _ |0 P:(DE-Juel1)VDB97674
|a Cherstvy, A.G.
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700 1 _ |0 P:(DE-Juel1)VDB106554
|a Pedraza, A.MN.
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700 1 _ |0 P:(DE-Juel1)VDB5728
|a Ingebrandt, S.
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700 1 _ |0 P:(DE-Juel1)128727
|a Schöning, M.J.
|b 5
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773 _ _ |0 PERI:(DE-600)1481091-8
|a 10.1002/pssa.201100710
|g Vol. 209, p. 925 - 934
|n 5
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|t Physica status solidi / A
|v 209
|x 0031-8965
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856 7 _ |u http://dx.doi.org/10.1002/pssa.201100710
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