TY  - JOUR
AU  - Schilbach, L.
AU  - Weiss, P.H.
AU  - Kuhn, J.
AU  - Timmermann, L.
AU  - Klosterkötter, J.
AU  - Huff, W.
TI  - Pharmacological treatment of deep brain stimulation-induced hypomania leads to clinical remission while preserving motor benefits.
JO  - Neurocase
VL  - 18
SN  - 1355-4794
CY  - London [u.a.]
PB  - Psychology Press
M1  - PreJuSER-21472
SP  - 152 - 159
PY  - 2012
N1  - Record converted from VDB: 12.11.2012
AB  - Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for Parkinson's disease, but can lead to adverse effects including psychiatric disturbance. Little is known about the risk factors and treatment options for such effects. Here, we describe a patient who reproducibly developed stimulation-induced hypomania when using ventrally located electrodes and responded well to pharmacological intervention while leaving the stimulation parameters unchanged to preserve motor benefits. In spite of clinical remission, [¹⁵O]-positron-emission-tomography (PET) demonstrated activation patterns similar to those reported during mania. This case, therefore, highlights an important treatment option of adverse effects of DBS, but also points toward the need for investigations of its risk factors and their underlying neurobiological mechanisms.
KW  - Antimanic Agents: therapeutic use
KW  - Bipolar Disorder: drug therapy
KW  - Bipolar Disorder: etiology
KW  - Clozapine: therapeutic use
KW  - Deep Brain Stimulation: adverse effects
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Parkinson Disease: therapy
KW  - Treatment Outcome
KW  - Valproic Acid: therapeutic use
KW  - Antimanic Agents (NLM Chemicals)
KW  - Clozapine (NLM Chemicals)
KW  - Valproic Acid (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:21919560
UR  - <Go to ISI:>//WOS:000302400900009
DO  - DOI:10.1080/13554794.2011.568502
UR  - https://juser.fz-juelich.de/record/21472
ER  -