Journal Article

PreJuSER-21472

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Pharmacological treatment of deep brain stimulation-induced hypomania leads to clinical remission while preserving motor benefits.

Schilbach, L. ; Weiss, P. H.FZJ* ; Kuhn, J. ; Timmermann, L. ; Klosterkötter, J. ; Huff, W.

2012
Psychology Press London [u.a.]

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Please use a persistent id in citations: doi:10.1080/13554794.2011.568502

Abstract: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for Parkinson's disease, but can lead to adverse effects including psychiatric disturbance. Little is known about the risk factors and treatment options for such effects. Here, we describe a patient who reproducibly developed stimulation-induced hypomania when using ventrally located electrodes and responded well to pharmacological intervention while leaving the stimulation parameters unchanged to preserve motor benefits. In spite of clinical remission, [¹⁵O]-positron-emission-tomography (PET) demonstrated activation patterns similar to those reported during mania. This case, therefore, highlights an important treatment option of adverse effects of DBS, but also points toward the need for investigations of its risk factors and their underlying neurobiological mechanisms.

Keyword(s): Antimanic Agents: therapeutic use (MeSH) ; Bipolar Disorder: drug therapy (MeSH) ; Bipolar Disorder: etiology (MeSH) ; Clozapine: therapeutic use (MeSH) ; Deep Brain Stimulation: adverse effects (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Parkinson Disease: therapy (MeSH) ; Treatment Outcome (MeSH) ; Valproic Acid: therapeutic use (MeSH) ; Antimanic Agents ; Clozapine ; Valproic Acid ; J ; Subthalamic nucleus (auto) ; Deep brain stimulation (auto) ; Parkinson's disease (auto) ; Stimulation-induced hypomania (auto) ; Pharmacological treatment (auto) ; Positron-emission-tomography (PET) (auto)

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (FUEK409) (FUEK409)
2. 89572 - (Dys-)function and Plasticity (POF2-89572) (POF2-89572)

Appears in the scientific report 2012

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Database coverage:
; Current Contents - Clinical Medicine ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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