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024 7 _ |2 DOI
|a 10.1080/13554794.2011.568502
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037 _ _ |a PreJuSER-21472
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Clinical Neurology
084 _ _ |2 WoS
|a Psychiatry
084 _ _ |2 WoS
|a Psychology
100 1 _ |a Schilbach, L.
|b 0
|0 P:(DE-HGF)0
245 _ _ |a Pharmacological treatment of deep brain stimulation-induced hypomania leads to clinical remission while preserving motor benefits.
260 _ _ |a London [u.a.]
|b Psychology Press
|c 2012
300 _ _ |a 152 - 159
336 7 _ |a Journal Article
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336 7 _ |a article
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440 _ 0 |a NeuroCase
|0 26026
|y 2
|v 18
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for Parkinson's disease, but can lead to adverse effects including psychiatric disturbance. Little is known about the risk factors and treatment options for such effects. Here, we describe a patient who reproducibly developed stimulation-induced hypomania when using ventrally located electrodes and responded well to pharmacological intervention while leaving the stimulation parameters unchanged to preserve motor benefits. In spite of clinical remission, [¹⁵O]-positron-emission-tomography (PET) demonstrated activation patterns similar to those reported during mania. This case, therefore, highlights an important treatment option of adverse effects of DBS, but also points toward the need for investigations of its risk factors and their underlying neurobiological mechanisms.
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|a Funktion und Dysfunktion des Nervensystems (FUEK409)
536 _ _ |a 89572 - (Dys-)function and Plasticity (POF2-89572)
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Antimanic Agents: therapeutic use
650 _ 2 |2 MeSH
|a Bipolar Disorder: drug therapy
650 _ 2 |2 MeSH
|a Bipolar Disorder: etiology
650 _ 2 |2 MeSH
|a Clozapine: therapeutic use
650 _ 2 |2 MeSH
|a Deep Brain Stimulation: adverse effects
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Middle Aged
650 _ 2 |2 MeSH
|a Parkinson Disease: therapy
650 _ 2 |2 MeSH
|a Treatment Outcome
650 _ 2 |2 MeSH
|a Valproic Acid: therapeutic use
650 _ 7 |0 0
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|a Antimanic Agents
650 _ 7 |0 5786-21-0
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|a Clozapine
650 _ 7 |0 99-66-1
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|a Valproic Acid
650 _ 7 |a J
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653 2 0 |2 Author
|a Subthalamic nucleus
653 2 0 |2 Author
|a Deep brain stimulation
653 2 0 |2 Author
|a Parkinson's disease
653 2 0 |2 Author
|a Stimulation-induced hypomania
653 2 0 |2 Author
|a Pharmacological treatment
653 2 0 |2 Author
|a Positron-emission-tomography (PET)
700 1 _ |a Weiss, P.H.
|b 1
|u FZJ
|0 P:(DE-Juel1)131748
700 1 _ |a Kuhn, J.
|b 2
|0 P:(DE-HGF)0
700 1 _ |a Timmermann, L.
|b 3
|0 P:(DE-HGF)0
700 1 _ |a Klosterkötter, J.
|b 4
|0 P:(DE-HGF)0
700 1 _ |a Huff, W.
|b 5
|0 P:(DE-HGF)0
773 _ _ |a 10.1080/13554794.2011.568502
|g Vol. 18, p. 152 - 159
|p 152 - 159
|q 18<152 - 159
|0 PERI:(DE-600)1497469-1
|t Neurocase
|v 18
|y 2012
|x 1355-4794
856 7 _ |u http://dx.doi.org/10.1080/13554794.2011.568502
909 C O |o oai:juser.fz-juelich.de:21472
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914 1 _ |y 2012
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