Journal Article

PreJuSER-21513

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Determination of heavy metal ions by microchip capillary electrophoresis coupled with contactless conductivity detection

Liu, B.FZJ* ; Zhang, Y.FZJ* ; Mayer, D.FZJ* ; Krause, H.-J.FZJ* ; Jin, Q. ; Zhao, J. ; Offenhäusser, A.FZJ* ; Xu, Y.

2012
Wiley-Blackwell Weinheim

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Please use a persistent id in citations: doi:10.1002/elps.201100626

Abstract: An integrated detection circuitry based on a lock-in amplifier was designed for contactless conductivity determination of heavy metals. Combined with a simple-structure electrophoresis microchip, the detection system is successfully utilized for the separation and determination of various heavy metals. The influences of the running buffer and detection conditions on the response of the detector have been investigated. Six millimole 2-morpholinoethanesulfonic acid + histidine were selected as buffer for its stable baseline and high sensitivity. The best signals were recorded with a frequency of 38 kHz and 20 V(pp). The results showed that Mn(2+), Cd(2+), Co(2+), and Cu(2+) can be successfully separated and detected within 100 s by our system. The detection limits for five heavy metals (Mn(2+), Pb(2+), Cd(2+), Co(2+), and Cu(2+)) were determined to range from about 0.7 to 5.4 μM. This microchip system performs a crucial step toward the realization of a simple, inexpensive, and portable analytical device for metal analysis.

Keyword(s): Electric Conductivity (MeSH) ; Electrophoresis, Microchip: instrumentation (MeSH) ; Electrophoresis, Microchip: methods (MeSH) ; Limit of Detection (MeSH) ; Metals, Heavy: analysis (MeSH) ; Metals, Heavy ; J ; Contactless conductivity detection (auto) ; Heavy metals (auto) ; Microchip capillary electrophoresis (auto)

Note: This work was supported by grants from the Science and Technology Commission of Shanghai Municipality (Grants No. 09JC1416500, 09391911500, 10391901600, 1052nm06100), the China Scholarship Council (CSC), the German Helmholtz Association, and the German BMBF at DLR (Grant CHW09/009).

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Contributing Institute(s):

1. Bioelektronik (ICS-8)
2. Bioelektronik (PGI-8)
3. Jülich-Aachen Research Alliance - Fundamentals of Future Information Technology (JARA-FIT)

Research Program(s):

1. Grundlagen für zukünftige Informationstechnologien (P42)
2. BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung (P45)

Appears in the scientific report 2012

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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