%0 Thesis
%A Wehrse, Eckhard
%T Stimulation of neuronal tissue using microelectrodes: experiments with a model system and simulations
%V 4352
%I RWTH Aachen
%V Master (Univ.)
%C Jülich
%M PreJuSER-21865
%B Berichte des Forschungszentrums Jülich
%P III, 120 p.
%D 2012
%Z Record converted from JUWEL: 18.07.2013
%Z Aachen, RWTH, Aachen, Diplomarbeit: Master Thesis
%X The electrical stimulation of neuronal tissue proofs to be a growing topic in current research both in physics, chemistry and in biomedical sciences [1] [2]. Insights of this field led to powerful techniques like Deep Brain Stimulation (DBS) as a standard therapy against idiopathic dystonia, Parkinson’s disease, essential tremor [3] [4] and severe forms of depression [5] [6] (see [7] for a list of reviews in the high frequency stimulation field of the last decade). A further field of application are medical prostheses like in the retina [8] or cochlea [9]. In theses cases an electrical stimulation is used to influence neuronal tissue in a designated manner, often by triggering action potentials. To excite the neuron (depolarisation), the stimulation pulse drives the extracellular space to (more) negative potentials leading to a smaller absolute value of the membrane potential, which remains still negative. If the potential difference over the axon membrane rises above a given value, an action potential occurs. The principle processes of generating a physiological action potential are well understood and reviewed in literature
%F PUB:(DE-HGF)19
%9 Master Thesis
%U https://juser.fz-juelich.de/record/21865