Master Thesis

PreJuSER-21865

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Stimulation of neuronal tissue using microelectrodes: experiments with a model system and simulations

Wehrse, E. (Corresponding author)FZJ*

2012
Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag Jülich

Please use a persistent id in citations: http://hdl.handle.net/2128/4618

Abstract: The electrical stimulation of neuronal tissue proofs to be a growing topic in current research both in physics, chemistry and in biomedical sciences [1] [2]. Insights of this field led to powerful techniques like Deep Brain Stimulation (DBS) as a standard therapy against idiopathic dystonia, Parkinson’s disease, essential tremor [3] [4] and severe forms of depression [5] [6] (see [7] for a list of reviews in the high frequency stimulation field of the last decade). A further field of application are medical prostheses like in the retina [8] or cochlea [9]. In theses cases an electrical stimulation is used to influence neuronal tissue in a designated manner, often by triggering action potentials. To excite the neuron (depolarisation), the stimulation pulse drives the extracellular space to (more) negative potentials leading to a smaller absolute value of the membrane potential, which remains still negative. If the potential difference over the axon membrane rises above a given value, an action potential occurs. The principle processes of generating a physiological action potential are well understood and reviewed in literature

Note: Record converted from JUWEL: 18.07.2013; Record converted from VDB: 12.11.2012
Note: Aachen, RWTH, Aachen, Diplomarbeit: Master Thesis

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Contributing Institute(s):

1. Bioelektronik (ICS-8)

Research Program(s):

1. BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung (P45)

Appears in the scientific report 2012

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Database coverage:

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