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000021865 1001_ $$0P:(DE-Juel1)VDB107378$$aWehrse, Eckhard$$b0$$eCorresponding author$$uFZJ
000021865 245__ $$aStimulation of neuronal tissue using microelectrodes: experiments with a model system and simulations
000021865 260__ $$aJülich$$bForschungszentrum Jülich GmbH Zentralbibliothek, Verlag$$c2012
000021865 300__ $$aIII, 120 p.
000021865 3367_ $$0PUB:(DE-HGF)19$$2PUB:(DE-HGF)$$aMaster Thesis
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000021865 4900_ $$aBerichte des Forschungszentrums Jülich$$v4352
000021865 502__ $$aAachen, RWTH, Aachen, Diplomarbeit: Master Thesis$$bMaster (Univ.)$$cRWTH Aachen$$d2012
000021865 500__ $$aRecord converted from JUWEL: 18.07.2013
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000021865 520__ $$aThe electrical stimulation of neuronal tissue proofs to be a growing topic in current research both in physics, chemistry and in biomedical sciences [1] [2]. Insights of this field led to powerful techniques like Deep Brain Stimulation (DBS) as a standard therapy against idiopathic dystonia, Parkinson’s disease, essential tremor [3] [4] and severe forms of depression [5] [6] (see [7] for a list of reviews in the high frequency stimulation field of the last decade). A further field of application are medical prostheses like in the retina [8] or cochlea [9]. In theses cases an electrical stimulation is used to influence neuronal tissue in a designated manner, often by triggering action potentials. To excite the neuron (depolarisation), the stimulation pulse drives the extracellular space to (more) negative potentials leading to a smaller absolute value of the membrane potential, which remains still negative. If the potential difference over the axon membrane rises above a given value, an action potential occurs. The principle processes of generating a physiological action potential are well understood and reviewed in literature
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000021865 655_7 $$aHochschulschrift$$xMaster Thesis (Univ.)
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