TY  - THES
AU  - Wehrse, Eckhard
TI  - Stimulation of neuronal tissue using microelectrodes: experiments with a model system and simulations
VL  - 4352
PB  - RWTH Aachen
VL  - Master (Univ.)
CY  - Jülich
M1  - PreJuSER-21865
T2  - Berichte des Forschungszentrums Jülich
SP  - III, 120 p.
PY  - 2012
N1  - Record converted from JUWEL: 18.07.2013
N1  - Aachen, RWTH, Aachen, Diplomarbeit: Master Thesis
AB  - The electrical stimulation of neuronal tissue proofs to be a growing topic in current research both in physics, chemistry and in biomedical sciences [1] [2]. Insights of this field led to powerful techniques like Deep Brain Stimulation (DBS) as a standard therapy against idiopathic dystonia, Parkinson’s disease, essential tremor [3] [4] and severe forms of depression [5] [6] (see [7] for a list of reviews in the high frequency stimulation field of the last decade). A further field of application are medical prostheses like in the retina [8] or cochlea [9]. In theses cases an electrical stimulation is used to influence neuronal tissue in a designated manner, often by triggering action potentials. To excite the neuron (depolarisation), the stimulation pulse drives the extracellular space to (more) negative potentials leading to a smaller absolute value of the membrane potential, which remains still negative. If the potential difference over the axon membrane rises above a given value, an action potential occurs. The principle processes of generating a physiological action potential are well understood and reviewed in literature
LB  - PUB:(DE-HGF)19
UR  - https://juser.fz-juelich.de/record/21865
ER  -