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@MASTERSTHESIS{Wehrse:21865,
author = {Wehrse, Eckhard},
title = {{S}timulation of neuronal tissue using microelectrodes:
experiments with a model system and simulations},
volume = {4352},
school = {RWTH Aachen},
type = {Master (Univ.)},
address = {Jülich},
publisher = {Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag},
reportid = {PreJuSER-21865},
series = {Berichte des Forschungszentrums Jülich},
pages = {III, 120 p.},
year = {2012},
note = {Record converted from JUWEL: 18.07.2013; Aachen, RWTH,
Aachen, Diplomarbeit: Master Thesis},
abstract = {The electrical stimulation of neuronal tissue proofs to be
a growing topic in current research both in physics,
chemistry and in biomedical sciences [1] [2]. Insights of
this field led to powerful techniques like Deep Brain
Stimulation (DBS) as a standard therapy against idiopathic
dystonia, Parkinson’s disease, essential tremor [3] [4]
and severe forms of depression [5] [6] (see [7] for a list
of reviews in the high frequency stimulation field of the
last decade). A further field of application are medical
prostheses like in the retina [8] or cochlea [9]. In theses
cases an electrical stimulation is used to influence
neuronal tissue in a designated manner, often by triggering
action potentials. To excite the neuron (depolarisation),
the stimulation pulse drives the extracellular space to
(more) negative potentials leading to a smaller absolute
value of the membrane potential, which remains still
negative. If the potential difference over the axon membrane
rises above a given value, an action potential occurs. The
principle processes of generating a physiological action
potential are well understood and reviewed in literature},
cin = {ICS-8},
ddc = {500},
cid = {I:(DE-Juel1)ICS-8-20110106},
pnm = {BioSoft: Makromolekulare Systeme und biologische
Informationsverarbeitung},
pid = {G:(DE-Juel1)FUEK505},
typ = {PUB:(DE-HGF)19},
url = {https://juser.fz-juelich.de/record/21865},
}