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000021950 0247_ $$2DOI$$a10.1002/elps.201100682
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000021950 084__ $$2WoS$$aBiochemical Research Methods
000021950 084__ $$2WoS$$aChemistry, Analytical
000021950 1001_ $$0P:(DE-Juel1)VDB94855$$aPosch, T.N.$$b0$$uFZJ
000021950 245__ $$aNonaqueous capillary electrophoresis–mass spectrometry: A versatile, straightforward tool for the analysis of alkaloids from psychoactive plant extracts
000021950 260__ $$aWeinheim$$bWiley-Blackwell$$c2012
000021950 300__ $$a1557 - 1566
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000021950 440_0 $$01792$$aElectrophoresis$$v33$$x0173-0835$$y11
000021950 500__ $$3POF3_Assignment on 2016-02-29
000021950 500__ $$aWe thank the Helmholtz Initiative and Networking Fund for financial support.
000021950 520__ $$aIn this study we show that a nonaqueous capillary electrophoresis mass spectrometry (NACE-MS) method carefully optimized by a design of experiment can be applied to a very large number of alkaloids in different plant extracts. It is possible to characterize the pattern of the psychoactive alkaloids in several plant samples and preparations thereof, each presenting different challenges in their analysis. The method is shown to be able to separate structurally closely related substances, diastereomers and further isobaric compounds, to separate members of different alkaloid classes within one run and to tolerate significant matrix load. A comparison with methods presented in the literature reveals that a near-generic NACE-MS method for the fast profiling of alkaloids in forensically relevant plant samples has been developed.
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000021950 650_2 $$2MeSH$$aElectrophoresis, Capillary: methods
000021950 650_2 $$2MeSH$$aIndole Alkaloids: analysis
000021950 650_2 $$2MeSH$$aIndole Alkaloids: chemistry
000021950 650_2 $$2MeSH$$aIndole Alkaloids: isolation & purification
000021950 650_2 $$2MeSH$$aLimit of Detection
000021950 650_2 $$2MeSH$$aMass Spectrometry: methods
000021950 650_2 $$2MeSH$$aPlant Extracts: chemistry
000021950 650_2 $$2MeSH$$aPsychotropic Drugs: chemistry
000021950 650_2 $$2MeSH$$aReproducibility of Results
000021950 650_2 $$2MeSH$$aStereoisomerism
000021950 650_7 $$00$$2NLM Chemicals$$aIndole Alkaloids
000021950 650_7 $$00$$2NLM Chemicals$$aPlant Extracts
000021950 650_7 $$00$$2NLM Chemicals$$aPsychotropic Drugs
000021950 650_7 $$2WoSType$$aJ
000021950 65320 $$2Author$$aDiastereomers
000021950 65320 $$2Author$$aIndole alkaloids
000021950 65320 $$2Author$$aNonaqueous capillary electrophoresis-mass spectrometry
000021950 65320 $$2Author$$aPlant extracts
000021950 65320 $$2Author$$aPsychoactive
000021950 7001_ $$0P:(DE-HGF)0$$aMartin, N.$$b1
000021950 7001_ $$0P:(DE-HGF)0$$aPütz, M.$$b2
000021950 7001_ $$0P:(DE-Juel1)VDB93008$$aHuhn, C.$$b3$$uFZJ
000021950 773__ $$0PERI:(DE-600)1475486-1$$a10.1002/elps.201100682$$gVol. 33, p. 1557 - 1566$$p1557 - 1566$$q33<1557 - 1566$$tElectrophoresis$$v33$$x0173-0835$$y2012
000021950 8567_ $$uhttp://dx.doi.org/10.1002/elps.201100682
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