Journal Article

PreJuSER-21950

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Nonaqueous capillary electrophoresis–mass spectrometry: A versatile, straightforward tool for the analysis of alkaloids from psychoactive plant extracts

Posch, T. N.FZJ* ; Martin, N. ; Pütz, M. ; Huhn, C.FZJ*

2012
Wiley-Blackwell Weinheim

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Please use a persistent id in citations: doi:10.1002/elps.201100682

Abstract: In this study we show that a nonaqueous capillary electrophoresis mass spectrometry (NACE-MS) method carefully optimized by a design of experiment can be applied to a very large number of alkaloids in different plant extracts. It is possible to characterize the pattern of the psychoactive alkaloids in several plant samples and preparations thereof, each presenting different challenges in their analysis. The method is shown to be able to separate structurally closely related substances, diastereomers and further isobaric compounds, to separate members of different alkaloid classes within one run and to tolerate significant matrix load. A comparison with methods presented in the literature reveals that a near-generic NACE-MS method for the fast profiling of alkaloids in forensically relevant plant samples has been developed.

Keyword(s): Electrophoresis, Capillary: methods (MeSH) ; Indole Alkaloids: analysis (MeSH) ; Indole Alkaloids: chemistry (MeSH) ; Indole Alkaloids: isolation & purification (MeSH) ; Limit of Detection (MeSH) ; Mass Spectrometry: methods (MeSH) ; Plant Extracts: chemistry (MeSH) ; Psychotropic Drugs: chemistry (MeSH) ; Reproducibility of Results (MeSH) ; Stereoisomerism (MeSH) ; Indole Alkaloids ; Plant Extracts ; Psychotropic Drugs ; J ; Diastereomers (auto) ; Indole alkaloids (auto) ; Nonaqueous capillary electrophoresis-mass spectrometry (auto) ; Plant extracts (auto) ; Psychoactive (auto)

Note: We thank the Helmholtz Initiative and Networking Fund for financial support.

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Contributing Institute(s):

1. Zentralabteilung für Chemische Analysen (ZCH)

Research Program(s):

1. Techniken, Innovation und Gesellschaft (TIG) (P47)

Appears in the scientific report 2012

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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