TY  - JOUR
AU  - Posch, T.N.
AU  - Martin, N.
AU  - Pütz, M.
AU  - Huhn, C.
TI  - Nonaqueous capillary electrophoresis–mass spectrometry: A versatile, straightforward tool for the analysis of alkaloids from psychoactive plant extracts
JO  - Electrophoresis
VL  - 33
SN  - 0173-0835
CY  - Weinheim
PB  - Wiley-Blackwell
M1  - PreJuSER-21950
SP  - 1557 - 1566
PY  - 2012
N1  - We thank the Helmholtz Initiative and Networking Fund for financial support.
AB  - In this study we show that a nonaqueous capillary electrophoresis mass spectrometry (NACE-MS) method carefully optimized by a design of experiment can be applied to a very large number of alkaloids in different plant extracts. It is possible to characterize the pattern of the psychoactive alkaloids in several plant samples and preparations thereof, each presenting different challenges in their analysis. The method is shown to be able to separate structurally closely related substances, diastereomers and further isobaric compounds, to separate members of different alkaloid classes within one run and to tolerate significant matrix load. A comparison with methods presented in the literature reveals that a near-generic NACE-MS method for the fast profiling of alkaloids in forensically relevant plant samples has been developed.
KW  - Electrophoresis, Capillary: methods
KW  - Indole Alkaloids: analysis
KW  - Indole Alkaloids: chemistry
KW  - Indole Alkaloids: isolation & purification
KW  - Limit of Detection
KW  - Mass Spectrometry: methods
KW  - Plant Extracts: chemistry
KW  - Psychotropic Drugs: chemistry
KW  - Reproducibility of Results
KW  - Stereoisomerism
KW  - Indole Alkaloids (NLM Chemicals)
KW  - Plant Extracts (NLM Chemicals)
KW  - Psychotropic Drugs (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:22736357
UR  - <Go to ISI:>//WOS:000305753600010
DO  - DOI:10.1002/elps.201100682
UR  - https://juser.fz-juelich.de/record/21950
ER  -