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000022221 084__ $$2WoS$$aNeurosciences
000022221 1001_ $$0P:(DE-Juel1)131745$$aVossel, S.$$b0$$uFZJ
000022221 245__ $$aDeconstructing the Architecture of Dorsal and Ventral Attention Systems with Dynamic Causal Modeling
000022221 260__ $$aWashington, DC$$bSoc.$$c2012
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000022221 440_0 $$03603$$aJournal of Neuroscience$$v32$$x0270-6474$$y31
000022221 500__ $$aS.V. is supported by the Deutsche Forschungsgemeinschaft ( DFG, Vo 1733/1-1). K.J.F. is supported by the Wellcome Trust. We are grateful to our colleagues from the Wellcome Trust Centre for Neuroimaging and the Cognitive Neuroscience group for valuable support and discussions. In particular, we thank Oliver Haumann for assistance during scanning.
000022221 520__ $$aAttentional orientation to a spatial cue and reorientation-after invalid cueing-are mediated by two distinct networks in the human brain. A bilateral dorsal frontoparietal network, comprising the intraparietal sulcus (IPS) and the frontal eye fields (FEF), controls the voluntary deployment of attention and may modulate visual cortex in preparation for upcoming stimulation. In contrast, reorienting attention to invalidly cued targets engages a right-lateralized ventral frontoparietal network comprising the temporoparietal junction (TPJ) and ventral frontal cortex. The present fMRI study investigated the functional architecture of these two attentional systems by characterizing effective connectivity during lateralized orienting and reorienting of attention, respectively. Subjects performed a modified version of Posner's location-cueing paradigm. Dynamic causal modeling (DCM) of regional responses in the dorsal and ventral network, identified in a conventional (SPM) whole-brain analysis, was used to compare different functional architectures. Bayesian model selection showed that top-down connections from left and right IPS to left and right visual cortex, respectively, were modulated by the direction of attention. Moreover, model evidence was highest for a model with directed influences from bilateral IPS to FEF, and reciprocal coupling between right and left FEF. Invalid cueing enhanced forward connections from visual areas to right TPJ, and directed influences from right TPJ to right IPS and IFG (inferior frontal gyrus). These findings shed further light on the functional organization of the dorsal and ventral attentional network and support a context-sensitive lateralization in the top-down (backward) mediation of attentional orienting and the bottom-up (forward) effects of invalid cueing.
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000022221 650_2 $$2MeSH$$aAdult
000022221 650_2 $$2MeSH$$aAnalysis of Variance
000022221 650_2 $$2MeSH$$aAttention: physiology
000022221 650_2 $$2MeSH$$aBayes Theorem
000022221 650_2 $$2MeSH$$aBrain Mapping
000022221 650_2 $$2MeSH$$aCues
000022221 650_2 $$2MeSH$$aEye Movements
000022221 650_2 $$2MeSH$$aFemale
000022221 650_2 $$2MeSH$$aFunctional Laterality
000022221 650_2 $$2MeSH$$aHumans
000022221 650_2 $$2MeSH$$aImage Processing, Computer-Assisted
000022221 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000022221 650_2 $$2MeSH$$aMale
000022221 650_2 $$2MeSH$$aModels, Biological
000022221 650_2 $$2MeSH$$aNonlinear Dynamics
000022221 650_2 $$2MeSH$$aOrientation: physiology
000022221 650_2 $$2MeSH$$aOxygen: blood
000022221 650_2 $$2MeSH$$aParietal Lobe: blood supply
000022221 650_2 $$2MeSH$$aParietal Lobe: physiology
000022221 650_2 $$2MeSH$$aPhotic Stimulation: methods
000022221 650_2 $$2MeSH$$aPrefrontal Cortex: blood supply
000022221 650_2 $$2MeSH$$aPrefrontal Cortex: physiology
000022221 650_2 $$2MeSH$$aReaction Time: physiology
000022221 650_2 $$2MeSH$$aSpace Perception: physiology
000022221 650_2 $$2MeSH$$aTime Factors
000022221 650_2 $$2MeSH$$aYoung Adult
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000022221 7001_ $$0P:(DE-Juel1)131747$$aWeidner, R.$$b1$$uFZJ
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