Journal Article

PreJuSER-22221

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Deconstructing the Architecture of Dorsal and Ventral Attention Systems with Dynamic Causal Modeling

Vossel, S.FZJ* ; Weidner, R.FZJ* ; Driver, J. ; Friston, K. J. ; Fink, G. R.FZJ*

2012
Soc. Washington, DC

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Please use a persistent id in citations: doi:10.1523/JNEUROSCI.0414-12.2012

Abstract: Attentional orientation to a spatial cue and reorientation-after invalid cueing-are mediated by two distinct networks in the human brain. A bilateral dorsal frontoparietal network, comprising the intraparietal sulcus (IPS) and the frontal eye fields (FEF), controls the voluntary deployment of attention and may modulate visual cortex in preparation for upcoming stimulation. In contrast, reorienting attention to invalidly cued targets engages a right-lateralized ventral frontoparietal network comprising the temporoparietal junction (TPJ) and ventral frontal cortex. The present fMRI study investigated the functional architecture of these two attentional systems by characterizing effective connectivity during lateralized orienting and reorienting of attention, respectively. Subjects performed a modified version of Posner's location-cueing paradigm. Dynamic causal modeling (DCM) of regional responses in the dorsal and ventral network, identified in a conventional (SPM) whole-brain analysis, was used to compare different functional architectures. Bayesian model selection showed that top-down connections from left and right IPS to left and right visual cortex, respectively, were modulated by the direction of attention. Moreover, model evidence was highest for a model with directed influences from bilateral IPS to FEF, and reciprocal coupling between right and left FEF. Invalid cueing enhanced forward connections from visual areas to right TPJ, and directed influences from right TPJ to right IPS and IFG (inferior frontal gyrus). These findings shed further light on the functional organization of the dorsal and ventral attentional network and support a context-sensitive lateralization in the top-down (backward) mediation of attentional orienting and the bottom-up (forward) effects of invalid cueing.

Keyword(s): Adult (MeSH) ; Analysis of Variance (MeSH) ; Attention: physiology (MeSH) ; Bayes Theorem (MeSH) ; Brain Mapping (MeSH) ; Cues (MeSH) ; Eye Movements (MeSH) ; Female (MeSH) ; Functional Laterality (MeSH) ; Humans (MeSH) ; Image Processing, Computer-Assisted (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Models, Biological (MeSH) ; Nonlinear Dynamics (MeSH) ; Orientation: physiology (MeSH) ; Oxygen: blood (MeSH) ; Parietal Lobe: blood supply (MeSH) ; Parietal Lobe: physiology (MeSH) ; Photic Stimulation: methods (MeSH) ; Prefrontal Cortex: blood supply (MeSH) ; Prefrontal Cortex: physiology (MeSH) ; Reaction Time: physiology (MeSH) ; Space Perception: physiology (MeSH) ; Time Factors (MeSH) ; Young Adult (MeSH) ; Oxygen ; J

Note: S.V. is supported by the Deutsche Forschungsgemeinschaft ( DFG, Vo 1733/1-1). K.J.F. is supported by the Wellcome Trust. We are grateful to our colleagues from the Wellcome Trust Centre for Neuroimaging and the Cognitive Neuroscience group for valuable support and discussions. In particular, we thank Oliver Haumann for assistance during scanning.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (FUEK409) (FUEK409)
2. 89572 - (Dys-)function and Plasticity (POF2-89572) (POF2-89572)

Appears in the scientific report 2012

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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