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|a pmc:PMC3432566
024 7 _ |2 DOI
|a 10.1523/JNEUROSCI.0414-12.2012
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037 _ _ |a PreJuSER-22221
041 _ _ |a eng
082 _ _ |a 590
084 _ _ |2 WoS
|a Neurosciences
100 1 _ |0 P:(DE-Juel1)131745
|a Vossel, S.
|b 0
|u FZJ
245 _ _ |a Deconstructing the Architecture of Dorsal and Ventral Attention Systems with Dynamic Causal Modeling
260 _ _ |a Washington, DC
|b Soc.
|c 2012
300 _ _ |a 10637 - 10648
336 7 _ |a Journal Article
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336 7 _ |a article
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440 _ 0 |0 3603
|a Journal of Neuroscience
|v 32
|x 0270-6474
|y 31
500 _ _ |a S.V. is supported by the Deutsche Forschungsgemeinschaft ( DFG, Vo 1733/1-1). K.J.F. is supported by the Wellcome Trust. We are grateful to our colleagues from the Wellcome Trust Centre for Neuroimaging and the Cognitive Neuroscience group for valuable support and discussions. In particular, we thank Oliver Haumann for assistance during scanning.
520 _ _ |a Attentional orientation to a spatial cue and reorientation-after invalid cueing-are mediated by two distinct networks in the human brain. A bilateral dorsal frontoparietal network, comprising the intraparietal sulcus (IPS) and the frontal eye fields (FEF), controls the voluntary deployment of attention and may modulate visual cortex in preparation for upcoming stimulation. In contrast, reorienting attention to invalidly cued targets engages a right-lateralized ventral frontoparietal network comprising the temporoparietal junction (TPJ) and ventral frontal cortex. The present fMRI study investigated the functional architecture of these two attentional systems by characterizing effective connectivity during lateralized orienting and reorienting of attention, respectively. Subjects performed a modified version of Posner's location-cueing paradigm. Dynamic causal modeling (DCM) of regional responses in the dorsal and ventral network, identified in a conventional (SPM) whole-brain analysis, was used to compare different functional architectures. Bayesian model selection showed that top-down connections from left and right IPS to left and right visual cortex, respectively, were modulated by the direction of attention. Moreover, model evidence was highest for a model with directed influences from bilateral IPS to FEF, and reciprocal coupling between right and left FEF. Invalid cueing enhanced forward connections from visual areas to right TPJ, and directed influences from right TPJ to right IPS and IFG (inferior frontal gyrus). These findings shed further light on the functional organization of the dorsal and ventral attentional network and support a context-sensitive lateralization in the top-down (backward) mediation of attentional orienting and the bottom-up (forward) effects of invalid cueing.
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Adult
650 _ 2 |2 MeSH
|a Analysis of Variance
650 _ 2 |2 MeSH
|a Attention: physiology
650 _ 2 |2 MeSH
|a Bayes Theorem
650 _ 2 |2 MeSH
|a Brain Mapping
650 _ 2 |2 MeSH
|a Cues
650 _ 2 |2 MeSH
|a Eye Movements
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Functional Laterality
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Image Processing, Computer-Assisted
650 _ 2 |2 MeSH
|a Magnetic Resonance Imaging
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Models, Biological
650 _ 2 |2 MeSH
|a Nonlinear Dynamics
650 _ 2 |2 MeSH
|a Orientation: physiology
650 _ 2 |2 MeSH
|a Oxygen: blood
650 _ 2 |2 MeSH
|a Parietal Lobe: blood supply
650 _ 2 |2 MeSH
|a Parietal Lobe: physiology
650 _ 2 |2 MeSH
|a Photic Stimulation: methods
650 _ 2 |2 MeSH
|a Prefrontal Cortex: blood supply
650 _ 2 |2 MeSH
|a Prefrontal Cortex: physiology
650 _ 2 |2 MeSH
|a Reaction Time: physiology
650 _ 2 |2 MeSH
|a Space Perception: physiology
650 _ 2 |2 MeSH
|a Time Factors
650 _ 2 |2 MeSH
|a Young Adult
650 _ 7 |0 7782-44-7
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700 1 _ |0 P:(DE-Juel1)131747
|a Weidner, R.
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700 1 _ |0 P:(DE-HGF)0
|a Driver, J.
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700 1 _ |0 P:(DE-HGF)0
|a Friston, K.J.
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700 1 _ |0 P:(DE-Juel1)131720
|a Fink, G.R.
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773 _ _ |0 PERI:(DE-600)1475274-8
|a 10.1523/JNEUROSCI.0414-12.2012
|g Vol. 32, p. 10637 - 10648
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|t The @journal of neuroscience
|v 32
|x 0270-6474
|y 2012
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432566
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