%0 Journal Article
%A Sun, N.
%A Funke, S.A.
%A Willbold, D.
%T Mirror image phage display - Generating stable therapeutically and diagnostically active peptides with biotechnological means
%J Journal of biotechnology
%V 161
%@ 0168-1656
%C Amsterdam [u.a.]
%I Elsevier Science
%M PreJuSER-22236
%P 121 - 125
%D 2012
%Z DW is supported by the CLIB-Graduate Cluster Industrial Biotechnology. We thank Andrew Dingley for proofreading of the manuscript.
%X Peptides are attracting increasing attention as therapeutics. D-enantiomeric peptides are remarkably resistant to in vivo proteolysis and elicit low immunogenic responses when compared with the respective L-peptides. Therefore, D-peptides can serve as therapeutic and early diagnosis agents for drug development. Here we discuss the application of mirror image phage display in pharmaceutical biotechnology aiming to identify protease resistant D-peptides with biotechnological approaches.
%K J (WoSType)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:22728425
%U <Go to ISI:>//WOS:000307297500007
%R 10.1016/j.jbiotec.2012.05.019
%U https://juser.fz-juelich.de/record/22236