Journal Article

PreJuSER-22236

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Mirror image phage display - Generating stable therapeutically and diagnostically active peptides with biotechnological means

Sun, N.FZJ* ; Funke, S. A.FZJ* ; Willbold, D.FZJ*

2012
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.jbiotec.2012.05.019

Abstract: Peptides are attracting increasing attention as therapeutics. D-enantiomeric peptides are remarkably resistant to in vivo proteolysis and elicit low immunogenic responses when compared with the respective L-peptides. Therefore, D-peptides can serve as therapeutic and early diagnosis agents for drug development. Here we discuss the application of mirror image phage display in pharmaceutical biotechnology aiming to identify protease resistant D-peptides with biotechnological approaches.

Keyword(s): J ; Mirror image phage display (auto) ; D-enantiomeric peptide (auto) ; Pharmaceutical biotechnology (auto) ; Drug discovery (auto)

Note: DW is supported by the CLIB-Graduate Cluster Industrial Biotechnology. We thank Andrew Dingley for proofreading of the manuscript.

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Contributing Institute(s):

1. Strukturbiochemie (ICS-6)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)
2. BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung (P45)

Appears in the scientific report 2012

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Database coverage:
; BIOSIS Previews ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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