TY  - JOUR
AU  - Sun, N.
AU  - Funke, S.A.
AU  - Willbold, D.
TI  - Mirror image phage display - Generating stable therapeutically and diagnostically active peptides with biotechnological means
JO  - Journal of biotechnology
VL  - 161
SN  - 0168-1656
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PreJuSER-22236
SP  - 121 - 125
PY  - 2012
N1  - DW is supported by the CLIB-Graduate Cluster Industrial Biotechnology. We thank Andrew Dingley for proofreading of the manuscript.
AB  - Peptides are attracting increasing attention as therapeutics. D-enantiomeric peptides are remarkably resistant to in vivo proteolysis and elicit low immunogenic responses when compared with the respective L-peptides. Therefore, D-peptides can serve as therapeutic and early diagnosis agents for drug development. Here we discuss the application of mirror image phage display in pharmaceutical biotechnology aiming to identify protease resistant D-peptides with biotechnological approaches.
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:22728425
UR  - <Go to ISI:>//WOS:000307297500007
DO  - DOI:10.1016/j.jbiotec.2012.05.019
UR  - https://juser.fz-juelich.de/record/22236
ER  -