TY  - JOUR
AU  - Schulte-Rüther, M.
AU  - Mainz, V.
AU  - Fink, G.R.
AU  - Herpertz-Dahlmann, B.
AU  - Konrad, K.
TI  - Theory of mind and the brain in anorexia nervosa: relation to treatment outcome.
JO  - Journal of the American Academy of Child and Adolescent Psychiatry
VL  - 51
SN  - 0890-8567
CY  - Kidlington [u.a.]
PB  - Elsevier
M1  - PreJuSER-22510
SP  - 832 - 841
PY  - 2012
N1  - This study was supported by the Bundesministerium fur Bildung und Forschung grant BMBF 01GV0602 (B.H.-D., K.K.).Dr. Fink has served as an editorial board member of Cortex, Zeitschrift fur Neuropsychologie and Fortschritte der Neurologie Psychiatrie. He has received royalties from the publication of the book 'Funktionelle MRT in Psychiotrie und Neurologie" and "Neurologische Differentialdiagnose," has received honoraria for speaking engagements from Teva, GlaxoSmithKline, and Boehringer Ingelheim, and has received research support from the Bundesministerium fur Bildung und Forschung and the Deutsche Forschungsgemeinschaft. Dr. Herpertz-Dohlmann has served as a consultant to Eli Lilly and Co. and has received industry research funding from Medice and Vifor. Dr. Konrad has served as an editorial board member of the Journal of Neural Transmission, the Journal of Child Psychology, and Zeitschrift fur Kinder-und Jugendpsychiatrie, has received speaking fees from Eli Lilly and Co., Novartis, and Medice, has received industry research funding from Vifor, and has received research support from the Bundesministerium fur Bildung und Forschung and the Deutsche Forschungsgemeinschaft. Drs. Schulte-Ruther and Mainz report no biomedical financial interests or potential conflicts of interest.
AB  - Converging evidence suggests deficits in theory-of-mind (ToM) processing in patients with anorexia nervosa (AN). The present study aimed at elucidating the neural mechanisms underlying ToM-deficits in AN.A total of 19 adolescent patients with AN and 21 age-matched controls were investigated using functional magnetic resonance imaging during performance of a ToM-task at two time points (in-patients: admission to hospital and discharge after weight recovery). Clinical outcomes in patients were determined 1 year after admission.Irrespective of the time point, AN patients showed reduced activation in middle and anterior temporal cortex and in the medial prefrontal cortex. Hypoactivation in the medial prefrontal cortex at admission to hospital (T1) was correlated with clinical outcome at follow-up.Hypoactivation in the brain network supporting theory of mind may be associated with a social-cognitive endophenotype reflecting impairments of social functioning in anorexia nervosa which is predictive for a poor outcome at 1-year follow-up.
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:22840554
UR  - <Go to ISI:>//WOS:000307128300011
DO  - DOI:10.1016/j.jaac.2012.06.007
UR  - https://juser.fz-juelich.de/record/22510
ER  -