Journal Article

PreJuSER-22510

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Theory of mind and the brain in anorexia nervosa: relation to treatment outcome.

Schulte-Rüther, M.FZJ* ; Mainz, V. ; Fink, G. R.FZJ* ; Herpertz-Dahlmann, B. ; Konrad, K.FZJ*

2012
Elsevier Kidlington [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/7554  doi:10.1016/j.jaac.2012.06.007

Abstract: Converging evidence suggests deficits in theory-of-mind (ToM) processing in patients with anorexia nervosa (AN). The present study aimed at elucidating the neural mechanisms underlying ToM-deficits in AN.A total of 19 adolescent patients with AN and 21 age-matched controls were investigated using functional magnetic resonance imaging during performance of a ToM-task at two time points (in-patients: admission to hospital and discharge after weight recovery). Clinical outcomes in patients were determined 1 year after admission.Irrespective of the time point, AN patients showed reduced activation in middle and anterior temporal cortex and in the medial prefrontal cortex. Hypoactivation in the medial prefrontal cortex at admission to hospital (T1) was correlated with clinical outcome at follow-up.Hypoactivation in the brain network supporting theory of mind may be associated with a social-cognitive endophenotype reflecting impairments of social functioning in anorexia nervosa which is predictive for a poor outcome at 1-year follow-up.

Keyword(s): J ; anorexia nervosa (auto) ; superior temporal cortex (auto) ; social cognition (auto) ; medial prefrontal cortex (auto) ; theory of mind (auto)

Note: This study was supported by the Bundesministerium fur Bildung und Forschung grant BMBF 01GV0602 (B.H.-D., K.K.).Dr. Fink has served as an editorial board member of Cortex, Zeitschrift fur Neuropsychologie and Fortschritte der Neurologie Psychiatrie. He has received royalties from the publication of the book 'Funktionelle MRT in Psychiotrie und Neurologie" and "Neurologische Differentialdiagnose," has received honoraria for speaking engagements from Teva, GlaxoSmithKline, and Boehringer Ingelheim, and has received research support from the Bundesministerium fur Bildung und Forschung and the Deutsche Forschungsgemeinschaft. Dr. Herpertz-Dohlmann has served as a consultant to Eli Lilly and Co. and has received industry research funding from Medice and Vifor. Dr. Konrad has served as an editorial board member of the Journal of Neural Transmission, the Journal of Child Psychology, and Zeitschrift fur Kinder-und Jugendpsychiatrie, has received speaking fees from Eli Lilly and Co., Novartis, and Medice, has received industry research funding from Vifor, and has received research support from the Bundesministerium fur Bildung und Forschung and the Deutsche Forschungsgemeinschaft. Drs. Schulte-Ruther and Mainz report no biomedical financial interests or potential conflicts of interest.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (FUEK409) (FUEK409)
2. 89571 - Connectivity and Activity (POF2-89571) (POF2-89571)

Appears in the scientific report 2012

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Database coverage:
; ; BIOSIS Previews ; Current Contents - Social and Behavioral Sciences ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Social Sciences Citation Index ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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