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@ARTICLE{Deeg:22704,
author = {Deeg, A.A. and Schrader, T.E. and Strzalka, H. and Pfizer,
J. and Moroder, L. and Zinth, W.},
title = {{A}myloid-{L}ike {S}tructures {F}ormed by {A}zobenzene
{P}eptides: {L}ight-{T}riggered {D}isassembly},
journal = {Spectroscopy: An International Journal},
volume = {27},
issn = {0887-6703},
address = {Springfield, Or.},
publisher = {Aster Pub. Corp.},
reportid = {PreJuSER-22704},
pages = {387 - 391},
year = {2012},
note = {The work was supported by the German Science Foundation,
SFB 749, and the Munich Center of Integrated Protein
Science, CIPSM. The University of Zurich did not contribute
to this work.},
abstract = {The light-driven disassembly process of amyloid-like
structures formed by azobenzene model peptides is studied by
time-resolved mid-IR spectroscopy from nanoseconds to
minutes. The investigated peptide consists of two amino acid
strands connected by the azobenzene switch. The peptides
aggregate to amyloid-like structures when the azobenzene
chromophore is in the trans-conformation. Illumination,
resulting in a trans-to cis-isomerization of the azobenzene,
leads to disaggregation of the aggregated structures. After
optical excitation and isomerization of the azobenzene, one
finds absorption changes which recover to a large extent on
the time scale of few nanoseconds. These early absorption
transients are assigned to the relaxation of vibrational
excess energy (heat) or to structural rearrangements of
isomerized azobenzene and the aggregated surroundings. It is
only on the time scale of minutes that spectral signatures
appear which are characteristic for the disassembly of the
aggregated structure.},
keywords = {J (WoSType)},
cin = {ICS-1 / JCNS (München) ; Jülich Centre for Neutron
Science JCNS (München) ; JCNS-FRM-II / JCNS-1},
ddc = {530},
cid = {I:(DE-Juel1)ICS-1-20110106 /
I:(DE-Juel1)JCNS-FRM-II-20110218 /
I:(DE-Juel1)JCNS-1-20110106},
pnm = {BioSoft: Makromolekulare Systeme und biologische
Informationsverarbeitung (FUEK505) / 544 - In-house Research
with PNI (POF2-544)},
pid = {G:(DE-Juel1)FUEK505 / G:(DE-HGF)POF2-544},
experiment = {EXP:(DE-MLZ)External-20140101},
shelfmark = {Biochemical Research Methods / Spectroscopy},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000306505500016},
doi = {10.1155/2012/108959},
url = {https://juser.fz-juelich.de/record/22704},
}