Journal Article

PreJuSER-22704

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Amyloid-Like Structures Formed by Azobenzene Peptides: Light-Triggered Disassembly

Deeg, A. A. ; Schrader, T. E.FZJ* ; Strzalka, H. ; Pfizer, J. ; Moroder, L. ; Zinth, W.

2012
Aster Pub. Corp. Springfield, Or.

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Please use a persistent id in citations: doi:10.1155/2012/108959

Abstract: The light-driven disassembly process of amyloid-like structures formed by azobenzene model peptides is studied by time-resolved mid-IR spectroscopy from nanoseconds to minutes. The investigated peptide consists of two amino acid strands connected by the azobenzene switch. The peptides aggregate to amyloid-like structures when the azobenzene chromophore is in the trans-conformation. Illumination, resulting in a trans-to cis-isomerization of the azobenzene, leads to disaggregation of the aggregated structures. After optical excitation and isomerization of the azobenzene, one finds absorption changes which recover to a large extent on the time scale of few nanoseconds. These early absorption transients are assigned to the relaxation of vibrational excess energy (heat) or to structural rearrangements of isomerized azobenzene and the aggregated surroundings. It is only on the time scale of minutes that spectral signatures appear which are characteristic for the disassembly of the aggregated structure.

Keyword(s): Polymers, Soft Nano Particles and Proteins (1st) ; Key Technologies (1st) ; Chemistry (2nd) ; J ; Peptides (auto) ; amyloid-disassembly (auto) ; azobenzene (auto) ; nanostructures (auto) ; time-resolved-vibrational spectroscopy (auto)

Note: The work was supported by the German Science Foundation, SFB 749, and the Munich Center of Integrated Protein Science, CIPSM. The University of Zurich did not contribute to this work.

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Contributing Institute(s):

1. Neutronenstreuung (ICS-1)
2. JCNS-FRM-II (JCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II)
3. Neutronenstreuung (JCNS-1)

Research Program(s):

1. BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung (FUEK505) (FUEK505)
2. 544 - In-house Research with PNI (POF2-544) (POF2-544)

Experiment(s):

1. External Measurement

Appears in the scientific report 2012

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Database coverage:
Current Contents - Social and Behavioral Sciences ; JCR ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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