Journal Article

PreJuSER-22934

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Long-Term Sorption and Sequestration Dynamics of the Antibiotic Sulfadiazine: A Batch Study

Sittig, S.FZJ* ; Kasteel, R.FZJ* ; Groeneweg, J.FZJ* ; Vereecken, H.FZJ*

2012
ASA [u.a.] Madison, Wis.

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Please use a persistent id in citations: doi:10.2134/jeq2011.0467

Abstract: Understanding the long-term sequestration of veterinary antibiotics into soil fractions with different bioavailability is important in terms of assessing their eco-toxicological impact. We performed 60-d batch sorption experiments with radiolabeled sulfadiazine (SDZ) using samples from two agricultural soils. Sequential extraction with CaCl/MeOH (easily accessible fraction), microwave (residual fraction, RES), and combustion (nonextractable residues, NER) was used to quantify the sequestration dynamics of the C-derived SDZ-equivalent concentration. Multiple harsh extractions allowed us to mathematically extrapolate to the amount of SDZ equivalents that can be potentially extracted, resulting in halving the NER fraction after 60 d. A modified two-stage model with irreversible sorption combined with global parameter optimization was able to display the sequestration dynamics. We demonstrated this with sterilized samples in which no transformation of the parent compound was observed. This also showed that transformation was primarily biologically driven. These modeling results verified the procedure, which was then applied to nontreated samples from both soils to estimate effective parameter values for SDZ-derived equivalents. Observed initial sorption, to which up to 20% of the kinetic sorption sites attributed, was included in the model. Both the RES and NER fractions reached a sorption plateau, with NER occupying about 30% of the kinetic fraction (RES+NER) for all soils. The sorption and sequestration of SDZ were soil-specific and dominated by kinetics. Sequestration in the RES fraction was much slower (characteristic time: 60 d) than the redistribution in the NER fraction (characteristic time: <6 d). The work presented here contributes to the prediction of the dynamics of (bio-)availability.

Keyword(s): J

Note: We would like to thank the German Research Foundation (DFG) for financial support (FOR 566), Bayer HealthCare (Wuppertal, Germany) for providing the radiolabeled sulfadiazine, and the Division of Soil Science (INRES) at the University of Bonn for analyzing the soil textures. Furthermore, we would like to acknowledge contributions made by Stephan Koppchen, who performed the Radio-HPLC measurements, as well as Max Gotta and Katharina Nobis, who provided laboratory support.

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Contributing Institute(s):

1. Agrosphäre (IBG-3)

Research Program(s):

1. Terrestrische Umwelt (P24)

Appears in the scientific report 2012

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Database coverage:
; BIOSIS Previews ; Current Contents - Agriculture, Biology and Environmental Sciences ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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