Journal Article

PreJuSER-23108

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Meta-analytic modeling reveals differential functional connectivity of the medial and lateral orbitofrontal cortex

Zald, D. H. ; McHugo, M. ; Ray, K. L. ; Glahn, D. C. ; Eickhoff, S. B.FZJ* ; Laird, A. R.

2014
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/cercor/bhs308

Abstract: The orbitofrontal cortex (OFC) is implicated in a broad range of behaviors and neuropsychiatric disorders. Anatomical tracing studies in nonhuman primates reveal differences in connectivity across subregions of the OFC, but data on the connectivity of the human OFC remain limited. We applied meta-analytic connectivity modeling in order to examine which brain regions are most frequently coactivated with the medial and lateral portions of the OFC in published functional neuroimaging studies. The analysis revealed a clear divergence in the pattern of connectivity for the medial OFC (mOFC) and lateral OFC (lOFC) regions. The lOFC showed coactivations with a network of prefrontal regions and areas involved in cognitive functions including language and memory. In contrast, the mOFC showed connectivity with default mode, autonomic, and limbic regions. Convergent patterns of coactivations were observed in the amygdala, hippocampus, striatum, and thalamus. A small number of regions showed connectivity specific to the anterior or posterior sectors of the OFC. Task domains involving memory, semantic processing, face processing, and reward were additionally analyzed in order to identify the different patterns of OFC functional connectivity associated with specific cognitive and affective processes. These data provide a framework for understanding the human OFC's position within widespread functional networks.

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)

Appears in the scientific report 2012
Notes: First published online: October 4, 2012

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Database coverage:
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