Journal Article

FZJ-2016-01759

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Franke, B. (Corresponding author) ; Stein, J. L. ; Ripke, S. ; Anttila, V. ; Hibar, D. P. ; van Hulzen, K. J. ; Arias-Vasquez, A. ; Smoller, J. W. ; Nichols, T. E. ; Neale, M. C. ; McIntosh, A. M. ; Lee, P. ; McMahon, F. J. ; Meyer-Lindenberg, A. ; Mattheisen, M. ; Andreassen, O. A. ; Gruber, O. ; Sachdev, P. S. ; Roiz-Santiañez, R. ; Saykin, A. J. ; Ehrlich, S. ; Mather, K. A. ; Turner, J. A. ; Schwarz, E. ; Thalamuthu, A. ; Yao, Y. ; Ho, Y. Y. ; Martin, N. G. ; Wright, M. J. ; Consortium, S. W. G. o. t. P. G. (Collaboration author) ; Consortium, P. E. I. (Collaboration author) ; 2, W. T. C. C. C. (Collaboration author) ; Consortium, E. (Collaboration author) ; O'Donovan, M. C. ; Thompson, P. M. ; Neale, B. M. ; Medland, S. E. ; Sullivan, P. F.

2016
Nature America New York, NY

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Please use a persistent id in citations: doi:10.1038/nn.4228

Abstract: Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)

Appears in the scientific report 2016

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; IF >= 15 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; No Authors Fulltext ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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