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000029267 084__ $$2WoS$$aPhysics, Multidisciplinary
000029267 1001_ $$0P:(DE-HGF)0$$aNguyen-Duong, C. J.$$b0
000029267 245__ $$aSurface anchoring reduces the lifetime of single specific bonds
000029267 260__ $$aLes Ulis$$bEDP Sciences$$c2003
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000029267 440_0 $$01996$$aEurophysics Letters$$v61$$x0295-5075$$y6
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000029267 520__ $$aWe investigated the force-induced dissociation of single specific bonds between protein A and immunoglobulin G. In these experiments both proteins were tethered to microbeads. Piconewton forces were applied by means of an ultrasoft spring. Upon bond formation the thermal fluctuations of this soft spring were reduced. This resulted in a sizeable contribution to the free enthalpy of bonding. Including this effect we calculated the relation between the lifetime of bonds connecting both microbeads and the lifetime of the bond between free molecules. We found that in the first case the lifetime depended on the stiffness of the force probe. Moreover, the lifetime was reduced by almost two orders of magnitude. Both predictions were verified in our experiments.
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000029267 7001_ $$0P:(DE-HGF)0$$aKoch, K.-W.$$b1
000029267 7001_ $$0P:(DE-Juel1)128833$$aMerkel, R.$$b2$$uFZJ
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000029267 8567_ $$uhttp://dx.doi.org/10.1209/epl/i2003-00311-6
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