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@ARTICLE{NguyenDuong:29267,
      author       = {Nguyen-Duong, C. J. and Koch, K.-W. and Merkel, R.},
      title        = {{S}urface anchoring reduces the lifetime of single specific
                      bonds},
      journal      = {epl},
      volume       = {61},
      issn         = {0295-5075},
      address      = {Les Ulis},
      publisher    = {EDP Sciences},
      reportid     = {PreJuSER-29267},
      pages        = {845 - 851},
      year         = {2003},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {We investigated the force-induced dissociation of single
                      specific bonds between protein A and immunoglobulin G. In
                      these experiments both proteins were tethered to microbeads.
                      Piconewton forces were applied by means of an ultrasoft
                      spring. Upon bond formation the thermal fluctuations of this
                      soft spring were reduced. This resulted in a sizeable
                      contribution to the free enthalpy of bonding. Including this
                      effect we calculated the relation between the lifetime of
                      bonds connecting both microbeads and the lifetime of the
                      bond between free molecules. We found that in the first case
                      the lifetime depended on the stiffness of the force probe.
                      Moreover, the lifetime was reduced by almost two orders of
                      magnitude. Both predictions were verified in our
                      experiments.},
      keywords     = {J (WoSType)},
      cin          = {IBI-1 / ISG-4},
      ddc          = {530},
      cid          = {I:(DE-Juel1)VDB57 / I:(DE-Juel1)VDB44},
      pnm          = {Neurowissenschaften / Kondensierte Materie},
      pid          = {G:(DE-Juel1)FUEK255 / G:(DE-Juel1)FUEK242},
      shelfmark    = {Physics, Multidisciplinary},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000181456800019},
      doi          = {10.1209/epl/i2003-00311-6},
      url          = {https://juser.fz-juelich.de/record/29267},
}