Journal Article

PreJuSER-3300

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A comparison between Gauss-Newton and Markov-chain Monte Carlo-based methods for inverting spectral induced-polarization data for Cole-Cole parameters more options

Chen, J. ; Kemna, A.FZJ* ; Hubbard, S. S.

2008
SEG Tulsa, Okla.

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Please use a persistent id in citations: doi:10.1190/1.2976115

Abstract: To determine the prevalence of conjunctivochalasis in patients with immune thyroid diseases, to determine whether there is any association between the 2 diseases, and to determine cytologic study of conjunctivochalasis through the cytology impression test.A clinical prospective cohort study carried out by the External Diseases Department in the Ophthalmology Sector and the Thyroid Department in the Endocrinology Sector at Federal University of Sao Paulo (UNIFESP). The patients included were divided into 2 groups following these inclusion criteria: a control group of 25 patients without thyroid diseases, confirmed after clinical and laboratory examinations (thyroid hormones), or any other ocular diseases. The study group consisted of 31 patients with thyroid diseases, the diagnosis of which was confirmed by the Endocrinology Sector. The thyroidopathies included were autoimmune diseases but excluded nonautoimmune diseases. A protocol endorsed by the UNIFESP was followed, using clinical and ophthalmological history, biomicroscopy, and impression cytology.Fifty-two percent of patients without thyroid diseases and 88% of patients with thyroid diseases presented with conjunctivochalasis. The risk ratio was 1.705 (Pr > chi(2) = 0.0038), indicating that there is an association between them. For the impression cytology in inferior bulbar conjunctiva, there was an association between the result of the impression cytology and conjunctivochalasis (Pearson chi(2) = 10.1190 Pr = 0.006).The prevalence of conjunctivochalasis in patients with autoimmune thyroid diseases was 88%. Patients with autoimmune thyroidopathy presented higher percentages of conjunctivochalasis than the control group, confirming the association between them. The cytologic study showed the highest prevalence of abnormal surface features in eyes with conjunctivochalasis.

Keyword(s): Adult (MeSH) ; Aged (MeSH) ; Conjunctiva: pathology (MeSH) ; Diagnosis, Differential (MeSH) ; Follow-Up Studies (MeSH) ; Humans (MeSH) ; Keratoconjunctivitis Sicca: epidemiology (MeSH) ; Keratoconjunctivitis Sicca: etiology (MeSH) ; Keratoconjunctivitis Sicca: pathology (MeSH) ; Middle Aged (MeSH) ; Prevalence (MeSH) ; Prospective Studies (MeSH) ; Severity of Illness Index (MeSH) ; Thyroiditis, Autoimmune: complications (MeSH) ; Thyroiditis, Autoimmune: pathology (MeSH) ; J

Note: This study was funded by the Department of Energy, Environmental Remediation Science Program (ERSP) grant DE-AC0376SF00098 to Susan Hubbard. We thank Martin Munch (formerly ICG-4, Forschungszentrum Julich, Germany) and Odilia Esser (ICG-4, Forschungszentrum Julich, Germany) who helped with the laboratory SIP measurements included in this study. We also thank the associate editor Dr. John Bradford, Dr. Louise Pellerin, and two anonymous reviewers for their insightful comments and suggestions.

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Research Program(s):

1. Terrestrische Umwelt (P24)

Appears in the scientific report 2008

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