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@ARTICLE{Takors:34923,
      author       = {Takors, R.},
      title        = {{M}odel-based analysis and optimization of an {ISPR}
                      approach using reactive extraction for pilot scale
                      {L}-{P}henylalanine production},
      journal      = {Biotechnology progress},
      volume       = {20},
      issn         = {8756-7938},
      address      = {Malden, MA},
      publisher    = {Wiley},
      reportid     = {PreJuSER-34923},
      pages        = {57 - 64},
      year         = {2004},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Based on experimental data from fermentation runs, as well
                      as from L-phenylalanine (l-Phe) separation studies, a simple
                      model is presented that describes the total ISPR approach
                      for on-line L-Phe separation. While fermentation process
                      modeling via a macrokinetic model revealed an L-Phe
                      inhibition constant of 20 +/- 1.35 g/L using recombinant E.
                      coli cells, the reactive-extraction process modeling
                      identified the L-Phe cation diffusion in the aqueous donor
                      film and the transport of the lowly soluble carrier/L-Phe
                      complex in the aqueous acceptor film as the most dominant
                      transfer steps. The corresponding mass transfer coefficients
                      were estimated as k(PheD) = 128 x 10(-7) cm/s (extraction)
                      and k(CPheA) = 178 x 10(-5) cm/s (back-extraction).
                      Simulation studies were performed for the total ISPR
                      approach, which gave hints for strategies of further process
                      optimization.},
      keywords     = {Algorithms / Bioreactors: microbiology / Computer
                      Simulation / Escherichia coli: growth $\&$ development /
                      Escherichia coli: metabolism / Fractional Precipitation /
                      Industrial Microbiology: methods / Kinetics / Models,
                      Biological / Models, Chemical / Phenylalanine: biosynthesis
                      / Phenylalanine: chemistry / Phenylalanine: isolation $\&$
                      purification / Pilot Projects / Quality Control /
                      Ultrafiltration: methods / Phenylalanine (NLM Chemicals) / J
                      (WoSType)},
      cin          = {IBT-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB56},
      pnm          = {Biotechnologie},
      pid          = {G:(DE-Juel1)FUEK256},
      shelfmark    = {Biotechnology $\&$ Applied Microbiology / Food Science $\&$
                      Technology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:14763824},
      UT           = {WOS:000188861300008},
      doi          = {10.1021/bp0257473},
      url          = {https://juser.fz-juelich.de/record/34923},
}