%0 Journal Article
%A Görtz, P.
%A Opatz, J.
%A Siebler, M.
%A Funke, S. A.
%A Willbold, D.
%A Lange-Asschenfeldt, C.
%T Transient reduction of spontaneous neuronal network activity by sublethal amyloid ß (1-42) peptide concentrations
%J Journal of neural transmission / Parkinson's disease and dementia section
%V 116
%@ 0936-3076
%C Wien [u.a.]
%I Springer
%M PreJuSER-3798
%P 351 - 355
%D 2009
%Z This study was supported by a grant from the Stiftung fur Altersforschung (Age Research Foundation) of the Heinrich-Heine-Universitat Dusseldorf (C. L.-A. and P. G.).
%X Soluble amyloid beta(1-42) (A beta(1-42)) peptide has recently been assigned a key role in early Alzheimer's disease (AD) pathophysiology accounting for synaptic dysfunction before amyloid plaque formation and neurodegeneration can occur. Following sublethal A beta(1-42) administration, we observed an acute but transient reduction of the spike and burst rate of spontaneously active cortical networks cultured on microelectrode arrays. This simple experimental system appears suitable for future long-term pharmacological and genetic studies of A beta(1-42) signaling, thus providing a valuable new tool in AD research.
%K Action Potentials: drug effects
%K Action Potentials: physiology
%K Amyloid beta-Peptides: administration & dosage
%K Amyloid beta-Peptides: metabolism
%K Amyloid beta-Peptides: pharmacology
%K Animals
%K Cell Culture Techniques
%K Cerebral Cortex: cytology
%K Electrophysiology
%K Microelectrodes
%K Nerve Net: drug effects
%K Nerve Net: physiology
%K Neurons: drug effects
%K Neurons: physiology
%K Peptide Fragments: administration & dosage
%K Peptide Fragments: metabolism
%K Peptide Fragments: pharmacology
%K Rats
%K Amyloid beta-Peptides (NLM Chemicals)
%K Peptide Fragments (NLM Chemicals)
%K amyloid beta-protein (1-42) (NLM Chemicals)
%K J (WoSType)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:19214376
%U <Go to ISI:>//WOS:000263897900011
%R 10.1007/s00702-009-0188-y
%U https://juser.fz-juelich.de/record/3798