guest ::
| Home > Publications database > Transient reduction of spontaneous neuronal network activity by sublethal amyloid ß (1-42) peptide concentrations |
| Home > Publications database > Transient reduction of spontaneous neuronal network activity by sublethal amyloid ß (1-42) peptide concentrations |
| Journal Article | PreJuSER-3798 |
; ; ; ; ;
2009
Springer
Wien [u.a.]
This record in other databases: 
Please use a persistent id in citations: doi:10.1007/s00702-009-0188-y
Abstract: Soluble amyloid beta(1-42) (A beta(1-42)) peptide has recently been assigned a key role in early Alzheimer's disease (AD) pathophysiology accounting for synaptic dysfunction before amyloid plaque formation and neurodegeneration can occur. Following sublethal A beta(1-42) administration, we observed an acute but transient reduction of the spike and burst rate of spontaneously active cortical networks cultured on microelectrode arrays. This simple experimental system appears suitable for future long-term pharmacological and genetic studies of A beta(1-42) signaling, thus providing a valuable new tool in AD research.
Keyword(s): Action Potentials: drug effects (MeSH) ; Action Potentials: physiology (MeSH) ; Amyloid beta-Peptides: administration & dosage (MeSH) ; Amyloid beta-Peptides: metabolism (MeSH) ; Amyloid beta-Peptides: pharmacology (MeSH) ; Animals (MeSH) ; Cell Culture Techniques (MeSH) ; Cerebral Cortex: cytology (MeSH) ; Electrophysiology (MeSH) ; Microelectrodes (MeSH) ; Nerve Net: drug effects (MeSH) ; Nerve Net: physiology (MeSH) ; Neurons: drug effects (MeSH) ; Neurons: physiology (MeSH) ; Peptide Fragments: administration & dosage (MeSH) ; Peptide Fragments: metabolism (MeSH) ; Peptide Fragments: pharmacology (MeSH) ; Rats (MeSH) ; Amyloid beta-Peptides ; Peptide Fragments ; amyloid beta-protein (1-42) ; J ; Alzheimer's disease (auto) ; A beta(1-42) (auto) ; Cortical neurons (auto) ; Neuronal network activity (auto) ; Microelectrode array (auto)
|
The record appears in these collections: |