000003798 001__ 3798
000003798 005__ 20200402205552.0
000003798 0247_ $$2pmid$$apmid:19214376
000003798 0247_ $$2DOI$$a10.1007/s00702-009-0188-y
000003798 0247_ $$2WOS$$aWOS:000263897900011
000003798 037__ $$aPreJuSER-3798
000003798 041__ $$aeng
000003798 082__ $$a610
000003798 084__ $$2WoS$$aClinical Neurology
000003798 084__ $$2WoS$$aNeurosciences
000003798 1001_ $$0P:(DE-HGF)0$$aGörtz, P.$$b0
000003798 245__ $$aTransient reduction of spontaneous neuronal network activity by sublethal amyloid ß (1-42) peptide concentrations
000003798 260__ $$aWien [u.a.]$$bSpringer$$c2009
000003798 300__ $$a351 - 355
000003798 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
000003798 3367_ $$2DataCite$$aOutput Types/Journal article
000003798 3367_ $$00$$2EndNote$$aJournal Article
000003798 3367_ $$2BibTeX$$aARTICLE
000003798 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000003798 3367_ $$2DRIVER$$aarticle
000003798 440_0 $$017861$$aJournal of Neural Transmission$$v116$$x0936-3076$$y3
000003798 500__ $$aThis study was supported by a grant from the Stiftung fur Altersforschung (Age Research Foundation) of the Heinrich-Heine-Universitat Dusseldorf (C. L.-A. and P. G.).
000003798 520__ $$aSoluble amyloid beta(1-42) (A beta(1-42)) peptide has recently been assigned a key role in early Alzheimer's disease (AD) pathophysiology accounting for synaptic dysfunction before amyloid plaque formation and neurodegeneration can occur. Following sublethal A beta(1-42) administration, we observed an acute but transient reduction of the spike and burst rate of spontaneously active cortical networks cultured on microelectrode arrays. This simple experimental system appears suitable for future long-term pharmacological and genetic studies of A beta(1-42) signaling, thus providing a valuable new tool in AD research.
000003798 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems$$cP33$$x0
000003798 588__ $$aDataset connected to Web of Science, Pubmed
000003798 650_2 $$2MeSH$$aAction Potentials: drug effects
000003798 650_2 $$2MeSH$$aAction Potentials: physiology
000003798 650_2 $$2MeSH$$aAmyloid beta-Peptides: administration & dosage
000003798 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000003798 650_2 $$2MeSH$$aAmyloid beta-Peptides: pharmacology
000003798 650_2 $$2MeSH$$aAnimals
000003798 650_2 $$2MeSH$$aCell Culture Techniques
000003798 650_2 $$2MeSH$$aCerebral Cortex: cytology
000003798 650_2 $$2MeSH$$aElectrophysiology
000003798 650_2 $$2MeSH$$aMicroelectrodes
000003798 650_2 $$2MeSH$$aNerve Net: drug effects
000003798 650_2 $$2MeSH$$aNerve Net: physiology
000003798 650_2 $$2MeSH$$aNeurons: drug effects
000003798 650_2 $$2MeSH$$aNeurons: physiology
000003798 650_2 $$2MeSH$$aPeptide Fragments: administration & dosage
000003798 650_2 $$2MeSH$$aPeptide Fragments: metabolism
000003798 650_2 $$2MeSH$$aPeptide Fragments: pharmacology
000003798 650_2 $$2MeSH$$aRats
000003798 650_7 $$00$$2NLM Chemicals$$aAmyloid beta-Peptides
000003798 650_7 $$00$$2NLM Chemicals$$aPeptide Fragments
000003798 650_7 $$00$$2NLM Chemicals$$aamyloid beta-protein (1-42)
000003798 650_7 $$2WoSType$$aJ
000003798 65320 $$2Author$$aAlzheimer's disease
000003798 65320 $$2Author$$aA beta(1-42)
000003798 65320 $$2Author$$aCortical neurons
000003798 65320 $$2Author$$aNeuronal network activity
000003798 65320 $$2Author$$aMicroelectrode array
000003798 7001_ $$0P:(DE-HGF)0$$aOpatz, J.$$b1
000003798 7001_ $$0P:(DE-HGF)0$$aSiebler, M.$$b2
000003798 7001_ $$0P:(DE-Juel1)VDB65869$$aFunke, S. A.$$b3$$uFZJ
000003798 7001_ $$0P:(DE-Juel1)132029$$aWillbold, D.$$b4$$uFZJ
000003798 7001_ $$0P:(DE-HGF)0$$aLange-Asschenfeldt, C.$$b5
000003798 773__ $$0PERI:(DE-600)2591260-4$$a10.1007/s00702-009-0188-y$$gVol. 116, p. 351 - 355$$p351 - 355$$q116<351 - 355$$tJournal of neural transmission / Parkinson's disease and dementia section$$v116$$x0936-3076$$y2009
000003798 8567_ $$uhttp://dx.doi.org/10.1007/s00702-009-0188-y
000003798 909CO $$ooai:juser.fz-juelich.de:3798$$pVDB
000003798 9131_ $$0G:(DE-Juel1)FUEK409$$bGesundheit$$kP33$$lFunktion und Dysfunktion des Nervensystems$$vFunktion und Dysfunktion des Nervensystems$$x0
000003798 9141_ $$y2009
000003798 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000003798 9201_ $$0I:(DE-Juel1)VDB942$$d31.12.2010$$gISB$$kISB-3$$lStrukturbiochemie$$x0
000003798 9201_ $$0I:(DE-82)080012_20140620$$gJARA$$kJARA-HPC$$lJülich Aachen Research Alliance - High-Performance Computing$$x1
000003798 970__ $$aVDB:(DE-Juel1)110188
000003798 980__ $$aVDB
000003798 980__ $$aConvertedRecord
000003798 980__ $$ajournal
000003798 980__ $$aI:(DE-Juel1)ICS-6-20110106
000003798 980__ $$aI:(DE-82)080012_20140620
000003798 980__ $$aUNRESTRICTED
000003798 981__ $$aI:(DE-Juel1)IBI-7-20200312
000003798 981__ $$aI:(DE-Juel1)ICS-6-20110106
000003798 981__ $$aI:(DE-Juel1)VDB1346