TY  - JOUR
AU  - Görtz, P.
AU  - Opatz, J.
AU  - Siebler, M.
AU  - Funke, S. A.
AU  - Willbold, D.
AU  - Lange-Asschenfeldt, C.
TI  - Transient reduction of spontaneous neuronal network activity by sublethal amyloid ß (1-42) peptide concentrations
JO  - Journal of neural transmission / Parkinson's disease and dementia section
VL  - 116
SN  - 0936-3076
CY  - Wien [u.a.]
PB  - Springer
M1  - PreJuSER-3798
SP  - 351 - 355
PY  - 2009
N1  - This study was supported by a grant from the Stiftung fur Altersforschung (Age Research Foundation) of the Heinrich-Heine-Universitat Dusseldorf (C. L.-A. and P. G.).
AB  - Soluble amyloid beta(1-42) (A beta(1-42)) peptide has recently been assigned a key role in early Alzheimer's disease (AD) pathophysiology accounting for synaptic dysfunction before amyloid plaque formation and neurodegeneration can occur. Following sublethal A beta(1-42) administration, we observed an acute but transient reduction of the spike and burst rate of spontaneously active cortical networks cultured on microelectrode arrays. This simple experimental system appears suitable for future long-term pharmacological and genetic studies of A beta(1-42) signaling, thus providing a valuable new tool in AD research.
KW  - Action Potentials: drug effects
KW  - Action Potentials: physiology
KW  - Amyloid beta-Peptides: administration & dosage
KW  - Amyloid beta-Peptides: metabolism
KW  - Amyloid beta-Peptides: pharmacology
KW  - Animals
KW  - Cell Culture Techniques
KW  - Cerebral Cortex: cytology
KW  - Electrophysiology
KW  - Microelectrodes
KW  - Nerve Net: drug effects
KW  - Nerve Net: physiology
KW  - Neurons: drug effects
KW  - Neurons: physiology
KW  - Peptide Fragments: administration & dosage
KW  - Peptide Fragments: metabolism
KW  - Peptide Fragments: pharmacology
KW  - Rats
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - Peptide Fragments (NLM Chemicals)
KW  - amyloid beta-protein (1-42) (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:19214376
UR  - <Go to ISI:>//WOS:000263897900011
DO  - DOI:10.1007/s00702-009-0188-y
UR  - https://juser.fz-juelich.de/record/3798
ER  -