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000003799 245__ $$aPrion infection - seeded fibrillization or more?
000003799 260__ $$aAustin, Tex.$$bLandes Bioscience$$c2008
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000003799 520__ $$aThe prion infection is a conversion of host encoded prion protein (PrP) from its cellular isoform PrPC into the pathological and infectious isoform PrPSc; the conversion process was investigated by in vitro studies using recombinant and cellular PrP and natural PrPSc. We present a brief summary of the results determined with our in vitro conversion system and the derived mechanistic models. We describe well characterized intermediates and precursor states during the conversion process, kinetic studies of spontaneous and seeded fibrillogenesis and the impact of the membrane environment.
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000003799 65320 $$2Author$$aprion protein conversion
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000003799 65320 $$2Author$$afibril
000003799 65320 $$2Author$$adimer
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000003799 7001_ $$0P:(DE-HGF)0$$aRiesner, D.$$b1
000003799 773__ $$0PERI:(DE-600)2267671-5$$gVol. 2, p. 67 - 72$$p67 - 72$$q2<67 - 72$$tPrion$$v2$$x1933-6896$$y2008
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