Journal Article

PreJuSER-3799

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Prion infection - seeded fibrillization or more?

Birkmann, E.FZJ* ; Riesner, D.

2008
Landes Bioscience Austin, Tex.

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Abstract: The prion infection is a conversion of host encoded prion protein (PrP) from its cellular isoform PrPC into the pathological and infectious isoform PrPSc; the conversion process was investigated by in vitro studies using recombinant and cellular PrP and natural PrPSc. We present a brief summary of the results determined with our in vitro conversion system and the derived mechanistic models. We describe well characterized intermediates and precursor states during the conversion process, kinetic studies of spontaneous and seeded fibrillogenesis and the impact of the membrane environment.

Keyword(s): J ; prion protein conversion (auto) ; seeding (auto) ; fibril (auto) ; dimer (auto) ; precursor state (auto) ; kinetics (auto) ; membrane (auto)

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Strukturbiochemie (ISB-3)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)

Appears in the scientific report 2008

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Database coverage:
JCR ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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