TY  - JOUR
AU  - Birkmann, E.
AU  - Riesner, D.
TI  - Prion infection - seeded fibrillization or more?
JO  - Prion
VL  - 2
SN  - 1933-6896
CY  - Austin, Tex.
PB  - Landes Bioscience
M1  - PreJuSER-3799
SP  - 67 - 72
PY  - 2008
N1  - Record converted from VDB: 12.11.2012
AB  - The prion infection is a conversion of host encoded prion protein (PrP) from its cellular isoform PrPC into the pathological and infectious isoform PrPSc; the conversion process was investigated by in vitro studies using recombinant and cellular PrP and natural PrPSc. We present a brief summary of the results determined with our in vitro conversion system and the derived mechanistic models. We describe well characterized intermediates and precursor states during the conversion process, kinetic studies of spontaneous and seeded fibrillogenesis and the impact of the membrane environment.
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000261469000007
UR  - https://juser.fz-juelich.de/record/3799
ER  -