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000038434 084__ $$2WoS$$aBiochemistry & Molecular Biology
000038434 084__ $$2WoS$$aCell Biology
000038434 1001_ $$0P:(DE-HGF)0$$aWitte, V.$$b0
000038434 245__ $$aHIV-1 Nef Mimics an Intgrin Receptor Signal that Recruits the Polycomb Group Protein Eed to the Plasma Membrane
000038434 260__ $$a[Cambridge, Mass.]$$bCell Press$$c2004
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000038434 520__ $$aThe Nef protein of human and simian immunodeficiency virus (HIV/SIV) is believed to interfere with T cell activation signals by forming a signaling complex at the plasma membrane. Composition and function of the complex are not fully understood. Here we report that Nef recruits the Polycomb Group (PcG) protein Eed, so far known as a nuclear factor and repressor of transcription, to the membrane of cells. The Nef-induced translocation of Eed led to a potent stimulation of Tat-dependent HIV transcription, implying that Eed removal from the nucleus is required for optimal Tat function. Similar to Nef action, activation of integrin receptors recruited Eed to the plasma membrane, also leading to enhanced Tat/Nef-mediated transcription. Our results suggest a link between membrane-associated activation processes and transcriptional derepression and demonstrate how HIV exploits this mechanism.
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000038434 7001_ $$0P:(DE-HGF)0$$aLaffert, B.$$b1
000038434 7001_ $$0P:(DE-HGF)0$$aRosorius, O.$$b2
000038434 7001_ $$0P:(DE-HGF)0$$aLischka, P.$$b3
000038434 7001_ $$0P:(DE-HGF)0$$aBlume, K.$$b4
000038434 7001_ $$0P:(DE-HGF)0$$aGaller, G.$$b5
000038434 7001_ $$0P:(DE-HGF)0$$aStilper, A.$$b6
000038434 7001_ $$0P:(DE-Juel1)132029$$aWillbold, D.$$b7$$uFZJ
000038434 7001_ $$0P:(DE-HGF)0$$aBlume, K.$$b8
000038434 7001_ $$0P:(DE-HGF)0$$aD'Aloja, P.$$b9
000038434 7001_ $$0P:(DE-HGF)0$$aSixt, M.$$b10
000038434 7001_ $$0P:(DE-HGF)0$$aKolanus, J.$$b11
000038434 7001_ $$0P:(DE-HGF)0$$aOtt, M.$$b12
000038434 7001_ $$0P:(DE-HGF)0$$aKolanus, W.$$b13
000038434 7001_ $$0P:(DE-HGF)0$$aSchuler, G.$$b14
000038434 7001_ $$0P:(DE-HGF)0$$aBaur, A. S.$$b15
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