Journal Article

PreJuSER-38434

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png HIV-1 Nef Mimics an Intgrin Receptor Signal that Recruits the Polycomb Group Protein Eed to the Plasma Membrane

Witte, V. ; Laffert, B. ; Rosorius, O. ; Lischka, P. ; Blume, K. ; Galler, G. ; Stilper, A. ; Willbold, D.FZJ* ; Blume, K. ; D'Aloja, P. ; Sixt, M. ; Kolanus, J. ; Ott, M. ; Kolanus, W. ; Schuler, G. ; Baur, A. S.

2004
Cell Press [Cambridge, Mass.]

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Please use a persistent id in citations: doi:10.1016/S1097-2765(04)00004-8

Abstract: The Nef protein of human and simian immunodeficiency virus (HIV/SIV) is believed to interfere with T cell activation signals by forming a signaling complex at the plasma membrane. Composition and function of the complex are not fully understood. Here we report that Nef recruits the Polycomb Group (PcG) protein Eed, so far known as a nuclear factor and repressor of transcription, to the membrane of cells. The Nef-induced translocation of Eed led to a potent stimulation of Tat-dependent HIV transcription, implying that Eed removal from the nucleus is required for optimal Tat function. Similar to Nef action, activation of integrin receptors recruited Eed to the plasma membrane, also leading to enhanced Tat/Nef-mediated transcription. Our results suggest a link between membrane-associated activation processes and transcriptional derepression and demonstrate how HIV exploits this mechanism.

Keyword(s): J

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Biologische Strukturforschung (IBI-2)

Research Program(s):

1. Neurowissenschaften (L01)

Appears in the scientific report 2004

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