Hauptseite > Publikationsdatenbank > HIV-1 Nef Mimics an Intgrin Receptor Signal that Recruits the Polycomb Group Protein Eed to the Plasma Membrane > print

001     38434
005     20200402205442.0
024 7 _ |2 DOI
|a 10.1016/S1097-2765(04)00004-8
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041 _ _ |a eng
082 _ _ |a 570
084 _ _ |2 WoS
|a Biochemistry & Molecular Biology
084 _ _ |2 WoS
|a Cell Biology
100 1 _ |a Witte, V.
|b 0
|0 P:(DE-HGF)0
245 _ _ |a HIV-1 Nef Mimics an Intgrin Receptor Signal that Recruits the Polycomb Group Protein Eed to the Plasma Membrane
260 _ _ |a [Cambridge, Mass.]
|b Cell Press
|c 2004
300 _ _ |a 179 - 190
336 7 _ |a Journal Article
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336 7 _ |a article
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440 _ 0 |a Molecular Cell
|x 1097-2765
|0 11941
|v 13
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a The Nef protein of human and simian immunodeficiency virus (HIV/SIV) is believed to interfere with T cell activation signals by forming a signaling complex at the plasma membrane. Composition and function of the complex are not fully understood. Here we report that Nef recruits the Polycomb Group (PcG) protein Eed, so far known as a nuclear factor and repressor of transcription, to the membrane of cells. The Nef-induced translocation of Eed led to a potent stimulation of Tat-dependent HIV transcription, implying that Eed removal from the nucleus is required for optimal Tat function. Similar to Nef action, activation of integrin receptors recruited Eed to the plasma membrane, also leading to enhanced Tat/Nef-mediated transcription. Our results suggest a link between membrane-associated activation processes and transcriptional derepression and demonstrate how HIV exploits this mechanism.
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700 1 _ |a Laffert, B.
|b 1
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700 1 _ |a Rosorius, O.
|b 2
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700 1 _ |a Lischka, P.
|b 3
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700 1 _ |a Blume, K.
|b 4
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700 1 _ |a Galler, G.
|b 5
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700 1 _ |a Stilper, A.
|b 6
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700 1 _ |a Willbold, D.
|b 7
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700 1 _ |a Blume, K.
|b 8
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700 1 _ |a D'Aloja, P.
|b 9
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700 1 _ |a Sixt, M.
|b 10
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700 1 _ |a Kolanus, J.
|b 11
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700 1 _ |a Ott, M.
|b 12
|0 P:(DE-HGF)0
700 1 _ |a Kolanus, W.
|b 13
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700 1 _ |a Schuler, G.
|b 14
|0 P:(DE-HGF)0
700 1 _ |a Baur, A. S.
|b 15
|0 P:(DE-HGF)0
773 _ _ |a 10.1016/S1097-2765(04)00004-8
|g Vol. 13, p. 179 - 190
|p 179 - 190
|q 13<179 - 190
|0 PERI:(DE-600)2001948-8
|t Molecular cell
|v 13
|y 2004
|x 1097-2765
909 C O |o oai:juser.fz-juelich.de:38434
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|l Funktion und Dysfunktion des Nervensystems
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914 1 _ |y 2004
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
920 1 _ |k IBI-2
|l Biologische Strukturforschung
|d 31.12.2006
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981 _ _ |a I:(DE-Juel1)ICS-6-20110106

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