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000045561 0247_ $$2DOI$$a10.1021/jp044980b
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000045561 084__ $$2WoS$$aChemistry, Physical
000045561 1001_ $$0P:(DE-Juel1)132009$$aKoenig, B. W.$$b0$$uFZJ
000045561 245__ $$aLipid ethanol interaction studied by NMR on bicelles
000045561 260__ $$aWashington, DC$$bSoc.$$c2005
000045561 300__ $$a7540 - 7547
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000045561 440_0 $$03694$$aJournal of Physical Chemistry B$$v109$$x1520-6106
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000045561 520__ $$aThe interaction of ethanol with phospholipids was studied in bicelles at a physiologically relevant ethanol concentration of 20 mM and a lipid content of 14 wt % by high-resolution NMR. Transient association of ethanol with magnetically aligned bicelles imparts a small degree of anisotropy to the solute. This anisotropy allows detection of residual (1)H-(1)H and (1)H-(13)C dipolar couplings, which are superimposed on scalar couplings. Residual (2)H NMR quadrupole splittings of isotope-labeled ethanol were measured as well. The analysis of residual tensorial interactions yielded information on the orientation and motions of ethanol in the membrane-bound state. The fraction of phosphatidylcholine-bound ethanol was determined independently by gas chromatography and NMR. About 4% of ethanol is bound to phosphatidylcholine at a bicelle concentration of 14 wt % at 40 degrees C. Free and bound ethanol are in rapid exchange. The lifetime of ethanol association with phosphatidylcholine membranes is of the order of a few nanoseconds.
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000045561 650_2 $$2MeSH$$aChemistry, Physical: methods
000045561 650_2 $$2MeSH$$aChromatography, Gas
000045561 650_2 $$2MeSH$$aDimyristoylphosphatidylcholine: chemistry
000045561 650_2 $$2MeSH$$aEthanol: chemistry
000045561 650_2 $$2MeSH$$aLipid Bilayers
000045561 650_2 $$2MeSH$$aLipids: chemistry
000045561 650_2 $$2MeSH$$aMagnetic Resonance Spectroscopy
000045561 650_2 $$2MeSH$$aMolecular Conformation
000045561 650_2 $$2MeSH$$aPhosphatidylcholines: chemistry
000045561 650_2 $$2MeSH$$aPhospholipids: chemistry
000045561 650_2 $$2MeSH$$aTime Factors
000045561 650_7 $$00$$2NLM Chemicals$$aLipid Bilayers
000045561 650_7 $$00$$2NLM Chemicals$$aLipids
000045561 650_7 $$00$$2NLM Chemicals$$aPhosphatidylcholines
000045561 650_7 $$00$$2NLM Chemicals$$aPhospholipids
000045561 650_7 $$013699-48-4$$2NLM Chemicals$$aDimyristoylphosphatidylcholine
000045561 650_7 $$064-17-5$$2NLM Chemicals$$aEthanol
000045561 650_7 $$2WoSType$$aJ
000045561 7001_ $$0P:(DE-HGF)0$$aGawrisch, K.$$b1
000045561 773__ $$0PERI:(DE-600)2006039-7$$a10.1021/jp044980b$$gVol. 109, p. 7540 - 7547$$p7540 - 7547$$q109<7540 - 7547$$tThe @journal of physical chemistry <Washington, DC> / B$$v109$$x1520-6106$$y2005
000045561 8567_ $$uhttp://hdl.handle.net/2128/706$$uhttp://dx.doi.org/10.1021/jp044980b
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