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000046864 0247_ $$2DOI$$a10.1146/annurev.physiol.63.1.235
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000046864 084__ $$2WoS$$aPhysiology
000046864 1001_ $$0P:(DE-Juel1)VDB728$$aKaupp, U. B.$$b0$$uFZJ
000046864 245__ $$aMolecular diversity of pacemaker ion channels
000046864 260__ $$aStanford, Calif.$$bAnnual Review [u.a.]$$c2001
000046864 300__ $$a235 - 257
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000046864 440_0 $$0503$$aAnnual Review of Physiology$$v63$$x0066-4278
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000046864 520__ $$aIonic currents activated by hyperpolarization and regulated by cyclic nucleotides were first discovered more than 20 years ago. Recently the molecular identity of the underlying channels has been unveiled. The structural features of the protein sequences are discussed and related to the mechanisms of activation, selectivity for cyclic nucleotides, and ion permeation. Coverage includes a comparison of the biophysical properties of recombinant and native channels and their significance for the physiological functions of these channels.
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000046864 650_2 $$2MeSH$$aAnimals
000046864 650_2 $$2MeSH$$aBiological Clocks: physiology
000046864 650_2 $$2MeSH$$aCyclic Nucleotide-Gated Cation Channels
000046864 650_2 $$2MeSH$$aGenetic Variation
000046864 650_2 $$2MeSH$$aHumans
000046864 650_2 $$2MeSH$$aIon Channels: genetics
000046864 650_2 $$2MeSH$$aIon Channels: metabolism
000046864 650_2 $$2MeSH$$aMolecular Sequence Data
000046864 650_2 $$2MeSH$$aMuscle Proteins
000046864 650_2 $$2MeSH$$aNerve Tissue Proteins
000046864 650_2 $$2MeSH$$aPotassium Channels
000046864 650_2 $$2MeSH$$aSequence Homology, Amino Acid
000046864 650_2 $$2MeSH$$aSinoatrial Node: physiology
000046864 650_7 $$00$$2NLM Chemicals$$aCyclic Nucleotide-Gated Cation Channels
000046864 650_7 $$00$$2NLM Chemicals$$aHCN2 potassium channel
000046864 650_7 $$00$$2NLM Chemicals$$aHCN4 protein, human
000046864 650_7 $$00$$2NLM Chemicals$$aIon Channels
000046864 650_7 $$00$$2NLM Chemicals$$aMuscle Proteins
000046864 650_7 $$00$$2NLM Chemicals$$aNerve Tissue Proteins
000046864 650_7 $$00$$2NLM Chemicals$$aPotassium Channels
000046864 650_7 $$00$$2NLM Chemicals$$ahyperpolarization-activated cation channel
000046864 650_7 $$2WoSType$$aJ
000046864 65320 $$2Author$$ahyperpolarization-activated current
000046864 65320 $$2Author$$apacemaker current
000046864 65320 $$2Author$$aHCN channels
000046864 65320 $$2Author$$acyclic nucleotides
000046864 7001_ $$0P:(DE-Juel1)VDB1505$$aSeifert, R.$$b1$$uFZJ
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000046864 9141_ $$y2001
000046864 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
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