Journal Article

PreJuSER-46864

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Molecular diversity of pacemaker ion channels

Kaupp, U. B.FZJ* ; Seifert, R.FZJ*

2001
Annual Review [u.a.] Stanford, Calif.

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Please use a persistent id in citations: doi:10.1146/annurev.physiol.63.1.235

Abstract: Ionic currents activated by hyperpolarization and regulated by cyclic nucleotides were first discovered more than 20 years ago. Recently the molecular identity of the underlying channels has been unveiled. The structural features of the protein sequences are discussed and related to the mechanisms of activation, selectivity for cyclic nucleotides, and ion permeation. Coverage includes a comparison of the biophysical properties of recombinant and native channels and their significance for the physiological functions of these channels.

Keyword(s): Animals (MeSH) ; Biological Clocks: physiology (MeSH) ; Cyclic Nucleotide-Gated Cation Channels (MeSH) ; Genetic Variation (MeSH) ; Humans (MeSH) ; Ion Channels: genetics (MeSH) ; Ion Channels: metabolism (MeSH) ; Molecular Sequence Data (MeSH) ; Muscle Proteins (MeSH) ; Nerve Tissue Proteins (MeSH) ; Potassium Channels (MeSH) ; Sequence Homology, Amino Acid (MeSH) ; Sinoatrial Node: physiology (MeSH) ; Cyclic Nucleotide-Gated Cation Channels ; HCN2 potassium channel ; HCN4 protein, human ; Ion Channels ; Muscle Proteins ; Nerve Tissue Proteins ; Potassium Channels ; hyperpolarization-activated cation channel ; J ; hyperpolarization-activated current (auto) ; pacemaker current (auto) ; HCN channels (auto) ; cyclic nucleotides (auto)

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Zelluläre Signalverarbeitung (IBI-1)

Research Program(s):

1. Zelluläre Signalverarbeitung (42.20.1)

Appears in the scientific report 2001

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