TY  - JOUR
AU  - Kaupp, U. B.
AU  - Seifert, R.
TI  - Molecular diversity of pacemaker ion channels
JO  - Annual review of physiology
VL  - 63
SN  - 0066-4278
CY  - Stanford, Calif.
PB  - Annual Review [u.a.]
M1  - PreJuSER-46864
SP  - 235 - 257
PY  - 2001
N1  - Record converted from VDB: 12.11.2012
AB  - Ionic currents activated by hyperpolarization and regulated by cyclic nucleotides were first discovered more than 20 years ago. Recently the molecular identity of the underlying channels has been unveiled. The structural features of the protein sequences are discussed and related to the mechanisms of activation, selectivity for cyclic nucleotides, and ion permeation. Coverage includes a comparison of the biophysical properties of recombinant and native channels and their significance for the physiological functions of these channels.
KW  - Animals
KW  - Biological Clocks: physiology
KW  - Cyclic Nucleotide-Gated Cation Channels
KW  - Genetic Variation
KW  - Humans
KW  - Ion Channels: genetics
KW  - Ion Channels: metabolism
KW  - Molecular Sequence Data
KW  - Muscle Proteins
KW  - Nerve Tissue Proteins
KW  - Potassium Channels
KW  - Sequence Homology, Amino Acid
KW  - Sinoatrial Node: physiology
KW  - Cyclic Nucleotide-Gated Cation Channels (NLM Chemicals)
KW  - HCN2 potassium channel (NLM Chemicals)
KW  - HCN4 protein, human (NLM Chemicals)
KW  - Ion Channels (NLM Chemicals)
KW  - Muscle Proteins (NLM Chemicals)
KW  - Nerve Tissue Proteins (NLM Chemicals)
KW  - Potassium Channels (NLM Chemicals)
KW  - hyperpolarization-activated cation channel (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:11181956
UR  - <Go to ISI:>//WOS:000168071900012
DO  - DOI:10.1146/annurev.physiol.63.1.235
UR  - https://juser.fz-juelich.de/record/46864
ER  -