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000047487 084__ $$2WoS$$aMultidisciplinary Sciences
000047487 1001_ $$0P:(DE-Juel1)VDB37578$$aNoguchi, H.$$b0$$uFZJ
000047487 245__ $$aShape Transitions of Fluid Vesicles and Red Blood Cells in Capillary Flows
000047487 260__ $$aWashington, DC$$bAcademy$$c2005
000047487 300__ $$a14159 - 14164
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000047487 440_0 $$05100$$aProceedings of the National Academy of Sciences of the United States of America$$v102$$x0027-8424
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000047487 520__ $$aThe dynamics of fluid vesicles and red blood cells (RBCs) in cylindrical capillary flow is studied by using a three-dimensional mesoscopic simulation approach. As flow velocity increases, a model RBC is found to transit from a nonaxisymmetric discocyteto an axisymmetric parachute shape (coaxial with the flow axis), while a fluid vesicle is found to transit from a discocyte to a prolate ellipsoid. Both shape transitions reduce the flow resistance. The critical velocities of the shape transitions are linearly dependent on the bending rigidity and on the shear modulus of the membrane. Slipper-like shapes of the RBC model are observed around the transition velocities. Our results are in good agreement with experiments on RBCs.
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000047487 650_2 $$2MeSH$$aBlood Circulation: physiology
000047487 650_2 $$2MeSH$$aBlood Flow Velocity: physiology
000047487 650_2 $$2MeSH$$aCapillaries: physiology
000047487 650_2 $$2MeSH$$aCapillary Resistance: physiology
000047487 650_2 $$2MeSH$$aCell Membrane: physiology
000047487 650_2 $$2MeSH$$aCell Shape: physiology
000047487 650_2 $$2MeSH$$aComputer Simulation
000047487 650_2 $$2MeSH$$aErythrocytes: cytology
000047487 650_2 $$2MeSH$$aErythrocytes: physiology
000047487 650_2 $$2MeSH$$aModels, Biological
000047487 650_2 $$2MeSH$$aRheology
000047487 650_2 $$2MeSH$$aTransport Vesicles: physiology
000047487 650_7 $$2WoSType$$aJ
000047487 65320 $$2Author$$amesoscale hydrodynamics simulation
000047487 65320 $$2Author$$amicrofluidics
000047487 65320 $$2Author$$ashape transformations
000047487 7001_ $$0P:(DE-Juel1)130665$$aGompper, G.$$b1$$uFZJ
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000047487 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242298
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