Journal Article

PreJuSER-47487

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Shape Transitions of Fluid Vesicles and Red Blood Cells in Capillary Flows

Noguchi, H.FZJ* ; Gompper, G.FZJ*

2005
Academy Washington, DC

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Please use a persistent id in citations: http://hdl.handle.net/2128/2684  doi:10.1073/pnas.0504243102

Abstract: The dynamics of fluid vesicles and red blood cells (RBCs) in cylindrical capillary flow is studied by using a three-dimensional mesoscopic simulation approach. As flow velocity increases, a model RBC is found to transit from a nonaxisymmetric discocyteto an axisymmetric parachute shape (coaxial with the flow axis), while a fluid vesicle is found to transit from a discocyte to a prolate ellipsoid. Both shape transitions reduce the flow resistance. The critical velocities of the shape transitions are linearly dependent on the bending rigidity and on the shear modulus of the membrane. Slipper-like shapes of the RBC model are observed around the transition velocities. Our results are in good agreement with experiments on RBCs.

Keyword(s): Blood Circulation: physiology (MeSH) ; Blood Flow Velocity: physiology (MeSH) ; Capillaries: physiology (MeSH) ; Capillary Resistance: physiology (MeSH) ; Cell Membrane: physiology (MeSH) ; Cell Shape: physiology (MeSH) ; Computer Simulation (MeSH) ; Erythrocytes: cytology (MeSH) ; Erythrocytes: physiology (MeSH) ; Models, Biological (MeSH) ; Rheology (MeSH) ; Transport Vesicles: physiology (MeSH) ; J ; mesoscale hydrodynamics simulation (auto) ; microfluidics (auto) ; shape transformations (auto)

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Theorie II (IFF-TH-II)

Research Program(s):

1. Kondensierte Materie (M02)

Appears in the scientific report 2005
Notes: This version is available at http://www.pnas.org, http://dx.doi.org/10.1073/pnas.0504243102

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Database coverage:

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