TY  - JOUR
AU  - Noguchi, H.
AU  - Gompper, G.
TI  - Shape Transitions of Fluid Vesicles and Red Blood Cells in Capillary Flows
JO  - Proceedings of the National Academy of Sciences of the United States of America
VL  - 102
SN  - 0027-8424
CY  - Washington, DC
PB  - Academy
M1  - PreJuSER-47487
SP  - 14159 - 14164
PY  - 2005
N1  - Record converted from VDB: 12.11.2012
AB  - The dynamics of fluid vesicles and red blood cells (RBCs) in cylindrical capillary flow is studied by using a three-dimensional mesoscopic simulation approach. As flow velocity increases, a model RBC is found to transit from a nonaxisymmetric discocyteto an axisymmetric parachute shape (coaxial with the flow axis), while a fluid vesicle is found to transit from a discocyte to a prolate ellipsoid. Both shape transitions reduce the flow resistance. The critical velocities of the shape transitions are linearly dependent on the bending rigidity and on the shear modulus of the membrane. Slipper-like shapes of the RBC model are observed around the transition velocities. Our results are in good agreement with experiments on RBCs.
KW  - Blood Circulation: physiology
KW  - Blood Flow Velocity: physiology
KW  - Capillaries: physiology
KW  - Capillary Resistance: physiology
KW  - Cell Membrane: physiology
KW  - Cell Shape: physiology
KW  - Computer Simulation
KW  - Erythrocytes: cytology
KW  - Erythrocytes: physiology
KW  - Models, Biological
KW  - Rheology
KW  - Transport Vesicles: physiology
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:16186506
C2  - pmc:PMC1242298
UR  - <Go to ISI:>//WOS:000232392900009
DO  - DOI:10.1073/pnas.0504243102
UR  - https://juser.fz-juelich.de/record/47487
ER  -